Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes - Report - MDSpire

Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes

  • By

  • Sebastián Ramiro Soria

  • Pablo Malagrino

  • Estefanía Sacconi

  • Graciela Martin

  • Nicolás Rovati

  • Verónica Plante

  • Florencia Grisel Ursino

  • María Florencia Biasoli

  • Natalia Alejandra Petriz

  • Paula Micone

  • Eugenia Maciero

  • Norberto Giglio

  • July 6, 2026

  • 0 min

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Clinical Report: Symptom Progression in Infants with Cow's Milk Protein Allergy

Overview

This study evaluated symptom progression and caregiver-reported outcomes in infants with cow's milk protein allergy (CMPA) following 28 days of treatment with an amino acid-based formula containing synbiotics. Improvements were observed in symptom scores and quality of life metrics.

Background

Cow's milk protein allergy (CMPA) is a prevalent food allergy in early childhood, affecting up to 3% of infants in developed countries. This study provides insights into symptom trajectories and caregiver experiences in a routine clinical setting.

Data Highlights

MeasureBaseline (Day 1)Day 28
CoMiSS10.1 (SD 4.6)3.5 (SD 2.2)
IGSQ-13Median (not specified)Median (not specified)
PO-SCORADMedian (not specified)Median (not specified)
FAQL-PBMedian (not specified)Median (not specified)

Key Findings

  • Mean CoMiSS decreased from 10.1 at baseline to 3.5 on Day 28.
  • Median scores for IGSQ-13 and PO-SCORAD showed improvement over the 28-day period, though specific values were not provided.
  • FAQL-PB scores decreased, indicating improved caregiver quality of life.
  • Caregiver-reported stool frequency and regurgitation improved over time.
  • One-year outcomes were descriptively assessed for 56 children with available follow-up data.

Clinical Implications

The findings indicate improvements in symptoms and caregiver-reported outcomes in infants with CMPA following treatment with an amino acid-based formula with synbiotics.

Conclusion

This study reports improvements in symptoms and caregiver-reported outcomes in infants with CMPA following treatment with an amino acid-based formula with synbiotics. Further research is warranted to establish causality and comparative effectiveness.

Related Resources & Content

  1. Frontiers | Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes
  2. Infection — Immune System Indicators and Infection Vulnerability in Preterm Infants Receiving Human Milk with Bovine Colostrum or Standard Fortifier: Insights from the FortiColos Trial Secondary Analysis
  3. Frontiers in Pediatrics — Extensively hydrolyzed versus intact milk protein formula and risk of necrotizing enterocolitis: a meta-analysis
  4. The Journal of Clinical Endocrinology & Metabolism — Saturation Effects on Branched-Chain Amino Acid Metabolism Following Increased Milk Protein Consumption in Healthy Adults
  5. The New Gastroenterologist — Type of Formula Could Increase NEC Risk in Preterm Infants
  6. https://bswtogether.org.uk/medicines/wp-content/uploads/sites/3/2026/06/CMPA-BSW-CMPA-Guidelines-Update-June-2026.pdf
  7. https://ntag.nhs.uk/wp-content/uploads/2025/09/NENC-Cows-Milk-Protein-Allergy-guidelines-approved-v1.1-August-2025.pdf
  8. Pełny tekst: Polish guidelines for the diagnosis and management of cow’s milk protein allergy [STADAMPL], Andrea Horvath - Alergologia Polska - Polish Journal of Allergology 1/2026
  9. Frontiers | Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study)
  10. Frontiers | Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes

Original Source(s)

Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes

  • by Sebastián Ramiro Soria, Pablo Malagrino, Estefanía Sacconi, Graciela Martin, Nicolás Rovati, Verónica Plante, Florencia Grisel Ursino, María Florencia Biasoli, Natalia Alejandra Petriz, Paula Micone, Eugenia Maciero, Norberto Giglio

  • July 6, 2026

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