Preoperative oral spicy stimulation for postoperative pain reduction after spinal surgery: a randomized controlled trial - Report - MDSpire

Preoperative oral spicy stimulation for postoperative pain reduction after spinal surgery: a randomized controlled trial

  • By

  • Dan Yu

  • Chengkun Tao

  • Yifan Zhang

  • Kunhong Li

  • Wei Liang

  • Yongqin Chen

  • Bin Shu

  • Guangyou Duan

  • Yamei Zhang

  • He Huang

  • May 25, 2026

  • 0 min

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Clinical Report: Effects of Preoperative Spicy Oral Stimulation on Pain Management

Overview

This study demonstrates that preoperative spicy oral stimulation significantly reduces postoperative pain intensity and analgesic consumption in patients undergoing spinal surgery. The intervention group experienced lower pain scores and required fewer supplemental analgesics compared to the placebo group.

Background

Incorporate specific statistics or references regarding opioid dependency risks.

Data Highlights

OutcomeSpicy Stimulation GroupPlacebo GroupMean Difference (MD)p-value
24-h AUC Rest Pain NRS60.0 [42.0–81.0]90.0 [64.5–120.0]–30.0 [95% CI, −45.0 to −15.0]< 0.001
24-h AUC Movement Pain NRS114.0 [84.0–135.0]153.0 [132.0–183.0]–39.0 [95% CI, −54.0 to −24.0]< 0.001
48-h AUC Rest Pain NRS87.0 [60.0–126.0]150.0 [108.0–186.0]–57.0 [−81.0 to −36.0]< 0.001
48-h AUC Movement Pain NRS210.0 [156.0–243.0]279.0 [225.0–342.0]–75.0 [−108.0 to −48.0]< 0.001
Supplemental Analgesics Required31.9%53.1%RR: 0.60 [0.37–0.98]
Total Analgesic Consumption (mg)116.0 ± 13.8126.0 ± 14.4–10.0 [−15.7 to −3.4]0.001

Key Findings

  • Preoperative spicy oral stimulation reduced 24-h AUC rest pain scores significantly compared to placebo.
  • Movement pain scores were also lower in the spicy stimulation group within the first 24 hours postoperatively.
  • Similar reductions in pain scores were observed at 48 hours for both rest and movement pain.
  • The spicy stimulation group required fewer supplemental analgesics than the placebo group.
  • Total analgesic consumption was lower in the spicy stimulation group, indicating an opioid-sparing effect.

Clinical Implications

Discuss potential limitations of the study and implications for broader clinical practice.

Conclusion

Preoperative spicy oral stimulation is a promising non-pharmacological intervention that can effectively reduce postoperative pain and analgesic requirements in spinal surgery patients.

Related Resources & Content

  1. Acta Neurochirurgica, 2026 -- Novel objective-subjective pain assessment score results in decreased opioid prescription after elective spine surgery: a prospective pilot study
  2. Obesity Surgery, 2022 -- The Impact of Intraperitoneal Local Anesthetic Administration on Post-Surgical Pain Levels in Bariatric Surgery: A Randomized Controlled Study
  3. Surgical Endoscopy, 2025 -- Postoperative Shoulder Discomfort Following Laparoscopic Antireflux Surgery: Results from a Randomized, Open-Label Study at a Single Institution
  4. Pain management after laminectomy: a systematic review and procedure-specific post-operative pain management (prospect) recommendations, European Spine Journal, 2020
  5. Frontiers, 2026 -- Preoperative Oral Spicy Stimulation for Postoperative Pain Reduction After Spinal Surgery: A Randomized Controlled Trial
  6. Obesity Surgery — Impact of Anesthesia Depth on Postoperative Pain Management Following Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Study
  7. Pain management after laminectomy: a systematic review and procedure-specific post-operative pain management (prospect) recommendations | European Spine Journal | Springer Nature Link
  8. Frontiers | Preoperative Oral Spicy Stimulation for Postoperative Pain Reduction After Spinal Surgery: A Randomized Controlled Trial

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