Evaluation of neutrophil oxidative burst capacity in relation to major adverse cardiac events and infection in patients with cardiovascular disease - Report - MDSpire

Evaluation of neutrophil oxidative burst capacity in relation to major adverse cardiac events and infection in patients with cardiovascular disease

  • By

  • Elias Haj-Yehia

  • Phillip Schulte

  • Christian Fehring

  • Sebastian Korste

  • Amir A. Mahabadi

  • Beda Jurgeleit

  • Astrid M. Westendorf

  • Ulrike B. Hendgen-Cotta

  • Tienush Rassaf

  • Matthias Totzeck

  • June 29, 2026

  • 0 min

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Assessment of Neutrophil Oxidative Burst Function in Relation to Major Adverse Cardiac Events

Overview

This study evaluates the relationship between neutrophil oxidative burst capacity and major adverse cardiac events (MACE) in patients with cardiovascular conditions.

Background

Neutrophils are critical components of the innate immune response, influencing both infection control and inflammation in cardiovascular disease. Their oxidative burst function, primarily mediated by reactive oxygen species (ROS), plays a dual role in disease progression and resolution.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

  • Neutrophils are the most abundant white blood cells and are key players in the immune response.
  • Neutrophil oxidative burst capacity is measured using oxygen consumption after stimulation with PMA.
  • ROS produced by neutrophils can contribute to both tissue damage and repair mechanisms in cardiovascular disease.
  • Neutrophils can accelerate atherosclerosis and contribute to myocardial damage during acute myocardial infarction.
  • High levels of neutrophil membrane-bound neprilysin are associated with reduced mortality risk in heart failure patients.

Clinical Implications

Clinicians should consider the dual role of neutrophils in both promoting and resolving cardiovascular disease when interpreting these findings.

Conclusion

The study highlights the relationship between neutrophil function and cardiovascular outcomes.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis
  2. European Journal of Preventive Cardiology -- Inflammation in the spotlight: neutrophil-to-lymphocyte ratio takes centre stage in atherosclerotic cardiovascular disease
  3. Clinical Research in Cardiology -- Elevated Neutrophil-to-Lymphocyte Ratio Linked to Cardiovascular Toxicity from Cancer Treatments in High-Risk Patients Receiving Immune Checkpoint Inhibitors
  4. Critical Care -- Neutrophil EMR3 dynamics in critically ill patients with sepsis: an ICU experience
  5. Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology | JACC
  6. Characterization of Neutrophil Extracellular Traps in Acute Myocardial Infarction: A Translational Study - PubMed
  7. Frontiers | Multimodal monitoring of neutrophil activity during cardiac surgery
  8. Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology | JACC
  9. Dihydrorhodamine Flow Cytometric Test, Blood - Mayo Clinic Laboratories | Pediatric Catalog
  10. Herzmedizin

Original Source(s)

Evaluation of neutrophil oxidative burst capacity in relation to major adverse cardiac events and infection in patients with cardiovascular disease

  • by Elias Haj-Yehia, Phillip Schulte, Christian Fehring, Sebastian Korste, Amir A. Mahabadi, Beda Jurgeleit, Astrid M. Westendorf, Ulrike B. Hendgen-Cotta, Tienush Rassaf, Matthias Totzeck

  • June 29, 2026

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