Impact of Hospice Care Plus Estazolam on Sleep and Psychological Distress in Advanced Gastrointestinal Cancer: A Real-World Observational Study - Report - MDSpire

Impact of Hospice Care Plus Estazolam on Sleep and Psychological Distress in Advanced Gastrointestinal Cancer: A Real-World Observational Study

  • By

  • Hu, Lihong

  • Cao, Donghui

  • Yuan, Xiaoya

  • Wang, Xiangtuan

  • Yuan, Haifeng

  • May 15, 2026

  • 0 min

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Clinical Report: Effects of Combined Hospice Care and Estazolam on Sleep Quality

Overview

This study evaluates the impact of hospice care combined with estazolam on sleep quality and mental health in patients with advanced gastrointestinal cancer. Results indicate significant improvements in sleep quality, anxiety, and depression in the hospice care group compared to routine nursing.

Background

Cancer remains a leading global health challenge, with millions affected by sleep disturbances that can severely impact quality of life. Addressing sleep quality and psychological well-being in cancer patients is crucial, particularly in advanced stages where palliative care becomes essential. This study explores a combined treatment approach to enhance patient outcomes.

Data Highlights

{'table': {'rows': [{'PSQI': 'Improvement', 'Routine Nursing': 'No significant change', 'P-value': '< .001'}, {'Anxiety': 'Improvement', 'Routine Nursing': 'No significant change', 'P-value': '< .001'}, {'Depression': 'Improvement', 'Routine Nursing': 'No significant change', 'P-value': '< .001'}, {'ESAS Appetite Subscale': 'Moderate-to-large effect', 'Routine Nursing': 'Not reported', 'P-value': '0.758'}]}}

Key Findings

  • Significant improvement in sleep quality (PSQI) in the hospice care group (P < .001).
  • Marked reduction in anxiety levels (SAS) in the hospice care group (P < .001).
  • Substantial decrease in depression scores (SDS) in the hospice care group (P < .001).
  • Overall quality of life improvements noted in the hospice care group, with large effect sizes across multiple indicators.
  • Combined treatment associated with better symptom management compared to routine nursing.

Clinical Implications

The findings suggest that integrating hospice care with pharmacological treatment can significantly enhance sleep quality and mental health in patients with advanced gastrointestinal cancer. Clinicians should consider this combined approach when developing care plans for similar patient populations.

Conclusion

This analysis underscores the benefits of hospice care combined with estazolam in improving sleep and psychological outcomes for patients with advanced gastrointestinal cancer, highlighting the importance of comprehensive care strategies.

Related Resources & Content

  1. BMC Psychiatry, 2025 -- Evaluating the psychosocial effects of cancer on sleep quality and mental health in elderly populations
  2. Journal of Neuro-Oncology, 2023 -- Frequency and Treatment of Sleep Disorders in Adults with Primary Brain Tumors and Their Caregivers: A Systematic Review
  3. Drugs - Real World Outcomes, 2015 -- Association Between Sleep Medication Use and Mortality Risk: Insights from the Hordaland Health Study
  4. The ASCO Post, 2014 -- Two Behavioral Interventions Help Cancer Patients Struggling With Sleep Issues, Penn Medicine Study Finds
  5. NCCN Guidelines® Insights: Distress Management, Version 1.2026 - PubMed
  6. Comparative efficacy of interventions for insomnia in cancer patients: a systematic review and network meta-analysis - PubMed
  7. The benefits of early palliative care on psychological well-being, functional status, and health-related quality of life among cancer patients and their caregivers: a systematic review and meta-analysis - PubMed
  8. NCCN Guidelines® Insights: Distress Management, Version 1.2026 - PubMed
  9. Comparative efficacy of interventions for insomnia in cancer patients: a systematic review and network meta-analysis - PubMed
  10. The benefits of early palliative care on psychological well-being, functional status, and health-related quality of life among cancer patients and their caregivers: a systematic review and meta-analysis - PubMed

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