Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy - Report - MDSpire
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Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy
Link Between Neonatal Sequential Organ Failure Assessment Scores and Neurological Outcomes in Infants with Hypoxic-Ischemic Encephalopathy
Overview
Revise to specify the types of neurological outcomes assessed and the predictive nature of nSOFA scores.
Background
Hypoxic-ischemic encephalopathy (HIE) is a significant cause of mortality and long-term disabilities in neonates. Despite the use of therapeutic hypothermia (TH), many infants with HIE experience poor neurological outcomes. Identifying risk factors for neurodevelopmental impairment (NDI) is crucial for improving management and outcomes in this vulnerable population.
Data Highlights
Measure
Result
Abnormal MRI (Weeke score ≥5)
36 (29.5%)
NDI at ≥12 months (Bayley-III)
23 (34.8%)
AUROC for abnormal Weeke score
0.79 (95% CI 0.70–0.88)
NPV for abnormal Weeke score
81%
PPV for abnormal Weeke score
74%
AUROC for NDI
0.78 (95% CI 0.66–0.89)
NPV for NDI
78%
PPV for NDI
75%
Key Findings
29.5% of infants had an abnormal MRI (Weeke score ≥5).
34.8% of infants met criteria for neurodevelopmental impairment (NDI) at ≥12 months.
Models using nSOFA scores and laboratory values showed good predictive accuracy for abnormal MRI and NDI.
Early physiologic and laboratory measures reflect underlying injury processes in infants with HIE.
Integration of early nSOFA scores may enhance risk stratification and prognostic assessment.
Clinical Implications
Clinicians should consider early nSOFA scores and laboratory values as potential indicators of neurological outcomes in infants with HIE. This approach may facilitate timely interventions and tailored care strategies to improve long-term outcomes for affected infants.
Conclusion
The study underscores the importance of early assessment of organ dysfunction and laboratory markers in predicting neurological outcomes in infants with HIE. These findings could inform clinical practices and enhance prognostic capabilities.
