Research progress of quercetin in infection at the maternal-fetal interface - Report - MDSpire

Research progress of quercetin in infection at the maternal-fetal interface

  • By

  • Jiena Shi

  • Jili Zhang

  • Wenjie Gong

  • Longhui Shen

  • May 28, 2026

  • 0 min

Share

Clinical Report: Advancements in Understanding Quercetin's Role in Maternal-Fetal Infection Management

Overview

This report reviews the potential of quercetin in managing maternal-fetal infections, highlighting its mechanisms of action and safety during pregnancy.

Background

Infections during pregnancy pose significant risks to both maternal and fetal health, contributing to adverse outcomes such as miscarriage and preeclampsia. Current treatments primarily rely on antibiotics, which have limitations including drug resistance and potential teratogenic effects.

Data Highlights

No numerical data available in the source material.

Key Findings

  • Quercetin regulates the function of decidual immune cells at the maternal-fetal interface.
  • It balances the cytokine network, which is crucial for immune tolerance and pathogen defense.
  • Quercetin targets pathogenic signaling pathways that could disrupt pregnancy.
  • It enhances the barrier function of trophoblast and decidual stromal cells.
  • The safety of quercetin during pregnancy has been discussed.

Clinical Implications

Further research is needed to establish quercetin's efficacy and safety profile in clinical settings.

Conclusion

Quercetin presents a promising avenue for the prevention and treatment of infection-related complications in pregnancy, warranting further investigation into its clinical applications.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Antimicrobial proteins and peptides in pregnancy: Guardians of the maternal–fetal frontier
  2. The Journal of Infectious Diseases, 2023 -- Maternal Immunization
  3. Infection, 2023 -- Effective Management of Glandular Tularemia with Azithromycin in a Pregnant Patient in Austria
  4. Archives of Gynecology and Obstetrics, 2026 -- Possible role of hyperimmunoglobulin in reducing the risk of maternal–fetal transmission of cytomegalovirus in the valacyclovir era: a case series
  5. What's New: Perinatal HIV Clinical Guidelines | NIH
  6. Screening for Syphilis in Pregnancy | ACOG
  7. Cytomegalovirus (CMV) in Pregnancy | ACOG
  8. Clinical Overview of Listeriosis | Listeria Infection | CDC
  9. Effectiveness of intrapartum azithromycin to prevent infections in planned vaginal births in low-income and middle-income countries: a post-hoc analysis of data from a multicentre, randomised, double-blind, placebo-controlled trial - PubMed
  10. Randomized controlled trial on the effects of different antibiotic regimens in preterm premature rupture of membranes after 34 weeks - PubMed
  11. Frontiers | Research Progress of Quercetin in Infection at the Maternal-Fetal Interface
  12. Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies - PubMed

Original Source(s)

Related Content