Clinical Report: Effectiveness and Safety of Chinese Herbal Decoctions in Breast Cancer
Overview
This network meta-analysis evaluates the efficacy and safety of traditional Chinese herbal decoctions in breast cancer treatment, involving 68 studies and 4,708 patients.
Background
Breast cancer is the most prevalent malignant tumor among women worldwide, with over two million new cases annually. Traditional treatments are associated with significant side effects, prompting interest in adjunctive therapies like traditional Chinese herbal decoctions.
Data Highlights
Outcome
Decoction
Odds Ratio (OR)/Mean Difference (MD)
Cumulative Probability (%)
Objective Response Rate
YHHYT
OR = 4.76 (95%CrI 1.25, 25)
81.42
Disease Control Rate
BZT
OR = 5.77 (95%CrI 1.59, 29)
74.66
CD4+/CD8+ Ratio
FJHQT
MD = 0.69 (95%CrI 0.2, 1.17)
88.00
Nausea and Vomiting Relief
BZT
OR = 0.25 (95%CrI 0.1, 0.57)
75.67
Key Findings
68 studies with 4,708 patients were included in the analysis.
YHHYT decoction showed the highest objective response rate with an OR of 4.76.
BZT decoction had the highest disease control rate with an OR of 5.77.
FJHQT decoction improved the CD4+/CD8+ ratio with a mean difference of 0.69.
BZT decoction significantly reduced nausea and vomiting with an OR of 0.25.
Clinical Implications
Further research is warranted to confirm these results and explore the mechanisms of action.
Conclusion
Continued investigation into these therapies is essential.
