Clinical Report: Impact of Time to Minimally Invasive Puncture and Drainage
Overview
Revise to specify that MIPD within 12 to 24 hours is associated with lower long-term mortality compared to earlier interventions.
Background
Spontaneous intracerebral hemorrhage (sICH) is a significant cause of morbidity and mortality, accounting for 10-15% of all strokes. Timely intervention is critical, as early hematoma evacuation can improve outcomes. However, the optimal timing for minimally invasive procedures such as MIPD remains unclear, necessitating further investigation into its impact on patient survival.
Data Highlights
Time Window (h)
Long-Term Mortality Rate (%)
0–6
48.48
6–12
50.56
12–24
30.34
Key Findings
MIPD within 12 to 24 hours is associated with reduced long-term mortality (OR 0.530; p = 0.03).
Patients treated within 0–6 hours and 6–12 hours had higher mortality rates compared to those treated within 12–24 hours.
The study included 214 patients with hematoma volumes ≥ 20 mL.
Secondary outcomes included GCS scores at discharge and mRS scores at 3 and 6 months.
Multivariate logistic regression and IPTW analysis were utilized to assess outcomes.
Clinical Implications
Clinicians should consider the timing of MIPD in patients with sICH, as interventions performed between 12 to 24 hours post-symptom onset may lead to better long-term survival outcomes. This highlights the importance of timely surgical evaluation and intervention in managing sICH.
Conclusion
The findings suggest that delaying MIPD to within 12 to 24 hours of symptom onset may improve long-term survival in patients with sICH. Further research is warranted to establish definitive timing guidelines for intervention.
