Clinical Report: Impact of Homocysteine and B-Vitamins on Young Saudi Patients
Overview
This study evaluates serum homocysteine and B-vitamin levels in 80 young patients with premature acute coronary syndrome (ACS) in Saudi Arabia. It identifies a weak inverse correlation between homocysteine and folate levels (rho = -0.254, p = 0.040), providing preliminary data on these biomarkers in this population.
Background
Premature coronary artery disease (PCAD) is a growing public health concern, particularly in younger populations. In Saudi Arabia, understanding the role of homocysteine and B-vitamins in cardiovascular health is crucial. This study provides descriptive data on these biomarkers in patients with premature ACS.
Data Highlights
Weak inverse correlation between homocysteine and folate levels (rho = -0.254, p = 0.040).
Key Findings
Weak inverse correlation between homocysteine and folate levels (rho = -0.254, p = 0.040).
No significant correlations between homocysteine and vitamins B12, B1, and B6.
Most patients presented with low SYNTAX score categories.
Exploratory ordinal regression suggested associations between selected biomarkers and SYNTAX score category, but findings should be interpreted cautiously due to the small sample size.
Clinical Implications
Further research is needed to explore the implications of these biomarkers on cardiovascular health in this demographic.
Conclusion
This exploratory study provides initial insights into the relationship between homocysteine, B-vitamins, and premature ACS in Saudi patients.
by Khalid Alfaraidy, Ayman Mohamed, Alexander Woodman, Rehab Al-Ansari, Yasser A. Al Malki, Fatimah S. Alayidh, Yaser Alnaam, Abdulrahman Al Husil, Mohamed I. Amin, Masniwati Sigem, Yousef M. Hawsawi, Lamiaa H. Al-Jamea
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