Characterization and Standardization Recommendations for Animal Models of Induced Diabetic Neurogenic Bladder
Overview
This study systematically summarizes the characteristics of animal models for Diabetic Neurogenic Bladder (DNB). Key findings include the predominance of SD rats and Wistar rats in modeling, with chemical induction methods being the most common.
Background
Diabetic Neurogenic Bladder (DNB) is a significant complication of diabetes mellitus, affecting 40%-60% of diabetic patients and potentially leading to severe renal damage. The lack of standardized animal models hampers research into the mechanisms and treatments for this condition.
Data Highlights
Animal Species
Modeling Method
STZ Dose (mg/kg)
Modeling Cycle (weeks)
SD rats, Wistar rats, C57BL/6 mice
Chemical induction (STZ), STZ + high-sugar/high-fat diet
60 (single injection)
8
Key Findings
Primary animal species used for DNB models include SD rats, Wistar rats, and C57BL/6 mice.
Male animals accounted for 82.39% of the total subjects in the studies analyzed.
The most common chemical induction method was streptozotocin (STZ), used in 74.15% of cases.
The typical modeling cycle for DNB was found to be 8 weeks.
Core criteria for successful modeling included blood glucose, urodynamics, and glycated hemoglobin (HbA1c) measurements.
Existing studies showed biases, particularly in blinding procedures.
Clinical Implications
The findings highlight the characteristics of DNB animal models and the prevalence of certain modeling methods.
Conclusion
This study clarifies the current application status of DNB animal models and addresses the research gap existing in previous review articles.
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