Clinical Report: The Role of DHA-Induced MPV Enhancement in Coronary Artery Stenosis
Overview
This study investigates the relationship between serum DHA levels, mean platelet volume (MPV), and coronary artery disease (CAD) severity. It finds that lower DHA levels correlate with higher MPV and worse coronary stenosis.
Background
Cardiovascular disease (CVD) is a leading global health issue, with coronary artery disease (CAD) being a significant contributor. Platelet activation plays a crucial role in acute coronary events, making the understanding of biomarkers like mean platelet volume (MPV) essential for risk assessment. Omega-3 polyunsaturated fatty acids, particularly DHA, have been noted for their potential protective effects against CAD.
Data Highlights
Parameter
CAD Group
Control Group
P-value
DHA Levels
Lower
Higher
< 0.001
MPV Correlation with Gensini Score
Positive
-
P < 0.05
DHA as Protective Factor for MACE
HR = 0.83
-
P = 0.002
MPV as Risk Factor for MACE
HR = 1.22
-
P = 0.046
Key Findings
Serum DHA levels were significantly lower in CAD patients compared to controls (P < 0.001).
DHA was negatively correlated with MPV, PDW, and PLCR in CAD patients (all P < 0.05).
MPV, PDW, and PLCR showed weak positive correlations with Gensini scores (all P < 0.05).
MPV mediated the relationship between DHA and Gensini score (P = 0.034).
DHA was identified as an independent protective factor for MACE (HR = 0.83, P = 0.002).
The combination of high DHA and low MPV significantly reduced MACE risk (P = 0.0011).
Clinical Implications
The findings indicate that assessing both DHA levels and MPV can enhance risk stratification in CAD patients.
Conclusion
DHA is linked to the severity of coronary stenosis, with MPV serving as a mediating factor.
