Estimation of histopathological types from breast MRI findings using a large language model - Report - MDSpire

Estimation of histopathological types from breast MRI findings using a large language model

  • By

  • Rie Kanasaki

  • Kazufumi Suzuki

  • Takami Ota

  • Sadako Akashi-Tanaka

  • Yoji Nagashima

  • Shuji Sakai

  • April 14, 2026

  • 0 min

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Clinical Report: Utilizing a Large Language Model to Infer Histopathological Types from Breast MRI Observations

Overview

This study investigates the ability of a large language model (LLM) to predict histopathological types of breast cancer based on imaging findings from contrast-enhanced MRI reports. The findings suggest that LLMs can effectively interpret radiological descriptions to approximate histological diagnoses, which may enhance reporting quality and research cohort identification.

Background

The integration of artificial intelligence, particularly large language models, into radiology has the potential to improve diagnostic accuracy and efficiency. Understanding the relationship between imaging findings and histopathological characteristics is crucial for enhancing patient care and streamlining research efforts. This study explores the feasibility of using LLMs to bridge the gap between radiological observations and pathological diagnoses in breast cancer.

Data Highlights

No numerical data or trial data was presented in the source material.

Key Findings

  • LLMs can predict histopathological diagnoses from natural language descriptions of MRI findings.
  • The study utilized real-world MRI reports to assess the accuracy of LLM predictions.
  • Exclusion criteria included cases with benign lesions and those without corresponding pathological results.
  • The research was conducted following ethical guidelines and received Institutional Review Board approval.
  • LLMs may improve the quality of radiology reporting and facilitate automated cohort identification for research.

Clinical Implications

The findings indicate that LLMs could serve as a valuable tool in radiology, potentially enhancing the accuracy of histopathological predictions based on imaging reports. This integration may lead to improved patient management and more efficient research methodologies.

Conclusion

The study demonstrates the potential of LLMs to infer histopathological types from breast MRI observations, suggesting a promising avenue for enhancing diagnostic workflows in radiology.

References

  1. npj Digital Medicine, 2025 -- Large language models driven neural architecture search for universal and lightweight disease diagnosis on histopathology slide images
  2. npj Digital Medicine, 2026 -- CancerLLM: a large language model in cancer domain
  3. the asco post, 2026 -- Large Language Models May Generate Concise, Coherent Pathology Summaries, Reducing Physician Burden
  4. European Radiology, 2025 -- Differentiating Intra-Axial Primary Brain Tumors: A Comparison of Large Language Models Analyzing Structured MRI Reports Versus Radiologists Interpreting Images
  5. ACR, 2025 -- ACR Publishes BI-RADS v2025 Manual to Advance Breast Imaging Standards
  6. Breast Cancer Research, 2025 -- AI-driven MRI biomarker for triple-class HER2 expression classification in breast cancer: a large-scale multicenter study
  7. PubMed, 2023 -- Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: ASCO-College of American Pathologists Guideline Update
  8. ACR BI-RADS v2025 Manual Released
  9. Breast Cancer Research Article on MRI and Histopathology
  10. AI-driven MRI biomarker for triple-class HER2 expression classification in breast cancer: a large-scale multicenter study | Breast Cancer Research | Full Text
  11. Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: ASCO-College of American Pathologists Guideline Update - PubMed

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