Free water–mediated associations among choroid plexus enlargement, white matter lesions, and cognitive performance in type 2 diabetes mellitus - Report - MDSpire
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Free water–mediated associations among choroid plexus enlargement, white matter lesions, and cognitive performance in type 2 diabetes mellitus
Clinical Report: Associations of Choroid Plexus Enlargement and Cognitive Function in T2DM
Overview
This study investigates the relationships between choroid plexus enlargement, white matter hyperintensities, and cognitive function in individuals with type 2 diabetes mellitus (T2DM).
Background
Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder linked to various neurological complications, including cognitive decline. Understanding the relationship between brain structural changes, such as white matter hyperintensities, and cognitive function is crucial for managing T2DM-related cognitive impairments.
Data Highlights
Measure
T2DM Patients
Healthy Controls
CP Volume
Larger
Smaller
FW Fraction
Higher
Lower
PVS Volume
Larger
Smaller
PWMH Volume
Larger
Smaller
SDMT Scores
Lower
Higher
Key Findings
T2DM patients had larger choroid plexus volume and higher free water fraction compared to controls.
Lower cognitive performance was observed in T2DM patients, as indicated by Symbol Digit Modalities Test (SDMT) scores.
CP volume and FW fraction were independently associated with periventricular white matter hyperintensity (PWMH) volume.
FW fraction and PWMH were independently linked to cognitive performance measured by SDMT.
Mediation analyses indicated significant indirect effects of FW on the relationships between CP and PWMH, and between FW and SDMT.
Clinical Implications
Clinicians should consider factors related to choroid plexus volume and free water dynamics when assessing cognitive function in this population.
Conclusion
The study establishes a connection between glymphatic-related brain fluid alterations and cognitive performance in T2DM.
