Scrotal Elephantiasis Secondary to Hidradenitis Suppurativa: A Rare Case Report - Report - MDSpire

Scrotal Elephantiasis Secondary to Hidradenitis Suppurativa: A Rare Case Report

  • By

  • Qupp, Salem K.

  • Halayqa, Iyad M.

  • Zeidan, Mohammad M.

  • Al-Karaja, Layth

  • Alzeer Alhousseini, Majed F.I.

  • May 20, 2026

  • 0 min

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Clinical Report: Scrotal Elephantiasis Resulting from Hidradenitis Suppurativa

Overview

This report presents a rare case of scrotal elephantiasis due to hidradenitis suppurativa in a 34-year-old male. The patient underwent successful surgical excision, highlighting the importance of early intervention in managing this debilitating condition.

Background

Genital elephantiasis is a rare condition often resulting from chronic lymphatic dysfunction, typically associated with filarial infections but also linked to inflammatory conditions like hidradenitis suppurativa (HS). Scrotal involvement from HS is exceptionally rare and can lead to significant morbidity. Understanding this condition is crucial for timely diagnosis and intervention to improve patient outcomes.

Data Highlights

The patient presented with a scrotal mass measuring 20 × 16 × 6 cm, weighing approximately 6 kg, with histopathology showing reactive fibromyxoid changes.

Key Findings

  • Scrotal elephantiasis is a rare complication of hidradenitis suppurativa.
  • The patient had long-standing, treatment-refractory HS affecting multiple body areas.
  • Surgical excision via en bloc resection was performed, preserving both testes and spermatic cords.
  • Histopathological examination revealed no evidence of malignancy.
  • Early recognition and surgical intervention are critical to restore function and quality of life.

Clinical Implications

Healthcare professionals should consider hidradenitis suppurativa as a potential cause of scrotal elephantiasis in patients with chronic inflammatory skin conditions. Timely surgical intervention can significantly improve patient quality of life and prevent further complications.

Conclusion

This case underscores the rarity of scrotal elephantiasis due to hidradenitis suppurativa and the necessity for early surgical intervention to manage advanced lymphatic disease effectively.

Related Resources & Content

  1. International Journal of Colorectal Disease, 2026 -- Anoscrotal fistulas: causes and management in a 10-year French case series
  2. Hernia, 2010 -- Scrotal Swelling Associated with Urination: A Case Study
  3. Frontiers in Surgery, 2026 -- Suprainguinal ectopic scrotum: a case report
  4. Lymphology, 2023 -- THE DIAGNOSIS AND TREATMENT OF PERIPHERAL LYMPHEDEMA: 2023 CONSENSUS DOCUMENT OF THE INTERNATIONAL SOCIETY OF LYMPHOLOGY
  5. Cleveland Clinic -- Scrotal Lymphedema: Causes, Symptoms & Treatment
  6. Hernia — Management of a Giant Inguinoscrotal Hernia with Preoperative Pneumoperitoneum: A Case Study Highlighting an Unexpected Complication and Literature Review
  7. Massive scrotal lymphedema in hidradenitis suppurativa: the surgical management of a severe case
  8. European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment
  9. THE DIAGNOSIS AND TREATMENT OF PERIPHERAL LYMPHEDEMA: 2023 CONSENSUS DOCUMENT OF THE INTERNATIONAL SOCIETY OF LYMPHOLOGY | Lymphology
  10. Scrotal Lymphedema: Causes, Symptoms & Treatment
  11. Hidradenitis suppurativa: Management - UpToDate
  12. Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised, placebo-controlled, double-blind phase 3 trials - ScienceDirect
  13. Bimekizumab for the treatment of hidradenitis suppurativa - PMC
  14. Efficacy and Safety of Medical Interventions for Moderate to Severe Hidradenitis Suppurativa: A Living Systematic Review and Network Meta-Analysis | Dermatology | JAMA Dermatology | JAMA Network
  15. Surgical Management of Genital Lymphedema Using the Combined Charles' Procedure and Lymphatic Superficial Circumflex Iliac Artery Perforator Flap Transfer (CHASCIP) - PubMed
  16. Comparative analyses of hidradenitis suppurativa surgical methods: A systematic review and meta-analysis - ScienceDirect

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