The middle cerebral artery early branches classification (MCA-EB): a novel imaging-based approach - Report - MDSpire

The middle cerebral artery early branches classification (MCA-EB): a novel imaging-based approach

  • By

  • Arkadiusz Kacała

  • Małgorzata Milnerowicz-Bescond

  • Maciej Ziomek

  • Marek Łukasiewicz

  • Łukasz Noszczak

  • Weronika Wrona

  • Wiktoria Wdowiak

  • Mateusz Dorochowicz

  • Kamil Litwinowicz

  • Anna Zimny

  • Maciej Guziński

  • July 8, 2026

  • 0 min

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Clinical Report: A New Imaging Classification System for Early Branches of the MCA

Overview

This study proposes and validates a new imaging classification system for early branches of the middle cerebral artery (MCA) using computed tomographic angiography (CTA). The MCA-EB classification aims to standardize anatomical classification.

Background

The middle cerebral artery (MCA) is critical in supplying blood to significant brain regions and is often involved in neurovascular diseases. Existing classifications of early branches of the MCA are limited by small sample sizes and do not adequately represent anatomical variations.

Data Highlights

Branch TypeFrequencyMean Diameter (mm)
Early Temporal Branches (ETB)197/271 (72.7%)0.86
Early Frontal Branches (EFB)74/271 (27.3%)0.83

Key Findings

  • A total of 271 early branches (EBs) were identified in 215 MCAs (53.25%).
  • ETBs were more frequent than EFBs, with a ratio of 72.7% to 27.3% respectively.
  • The mean diameter of ETBs was 0.86 mm, while EFBs had a mean diameter of 0.83 mm.
  • No significant correlation was found between EB diameter and distance from the MCA origin.
  • The MCA-EB classification includes four types, ranging from absence of EBs (Type I) to combined variants (Type IV).

Clinical Implications

The MCA-EB classification system provides a standardized approach to categorizing early branches of the MCA.

Conclusion

The MCA-EB classification provides a simplified and standardized framework for categorizing early branches of the MCA.

Related Resources & Content

  1. Evaluating the Diagnostic Accuracy of the Berlin Classification for Complex Middle Cerebral Artery Aneurysms: Insights from a Study Focused on Giant Aneurysms, European Radiology, 2020
  2. MRI of Vessel Walls in Moyamoya Disease: Variations in Arterial Wall Enhancement Related to Age, Affected Arteries, and Disease Progression, European Radiology, 2023
  3. Middle cerebral artery fenestration presenting with cerebral ischemia: a case report and review of the literature, Frontiers in Medicine, 2026
  4. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association, 2026
  5. Acta Neurochirurgica — Superficial Temporal Artery to Middle Cerebral Artery (STA-MCA) bypass: How I do it
  6. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association
  7. Thrombectomy for Distal Medium Vessel Occlusion: A Meta‐Analysis of Randomized Controlled Trials - PMC
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