Deep Learning Algorithms Versus Radiologists in Digital Breast Tomosynthesis for Breast Cancer Detection: Systematic Review and Meta-Analysis - Report - MDSpire

Deep Learning Algorithms Versus Radiologists in Digital Breast Tomosynthesis for Breast Cancer Detection: Systematic Review and Meta-Analysis

  • By

  • Shewen Lyu

  • Zepeng Wang

  • Yujing Mu

  • Luyao Wang

  • Xiaohua Pei

  • May 6, 2026

  • 0 min

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Clinical Report: Comparative Analysis of Deep Learning Models and Radiologists in Detecting Breast Cancer

Overview

This systematic review and meta-analysis evaluates the diagnostic performance of deep learning (DL) algorithms versus radiologists in detecting breast cancer via digital breast tomosynthesis (DBT). The analysis includes data from 38,565 patients, highlighting the potential of DL to enhance detection rates while addressing challenges such as false positives and negatives.

Background

Breast cancer remains the most commonly diagnosed cancer and a leading cause of cancer mortality among women globally. The transition to digital breast tomosynthesis (DBT) has improved detection rates but also introduced challenges in interpretation, particularly regarding false positives and negatives. The integration of deep learning algorithms aims to assist radiologists in overcoming these challenges and improving diagnostic accuracy.

Data Highlights

The meta-analysis included data from 38,565 patients across various studies, comparing the performance of DL algorithms and radiologists.

Key Findings

  • DBT significantly improves cancer detection rates compared to traditional digital mammography.
  • Deep learning algorithms show potential in enhancing lesion detection and classification.
  • Challenges with false positives and false negatives persist, particularly for certain breast cancer subtypes.
  • The performance of DL algorithms varies based on the experience level of radiologists.
  • Increased image volume from DBT may lead to radiologist fatigue and cognitive overload.

Clinical Implications

Radiologists should consider the integration of deep learning algorithms to enhance diagnostic accuracy in breast cancer detection. Continuous training and experience remain crucial in interpreting DBT images effectively, particularly in light of the challenges posed by false positives and negatives.

Conclusion

The findings underscore the importance of combining deep learning technologies with radiologist expertise to improve breast cancer detection rates. Ongoing research and development in this area are essential to optimize diagnostic performance.

Related Resources & Content

  1. European Radiology, 2025 -- A Systematic Review and Meta-Analysis of Deep Learning Approaches for Diagnosing Breast Cancer via MRI
  2. European Radiology, 2024 -- Comparative Analysis of Deep Learning Algorithms and Radiologist Expertise in Lung Cancer Diagnosis via Chest CT: A Systematic Review
  3. European Radiology, 2023 -- Evaluating the Precision of Automated ACR BI-RADS Breast Density Assessment Through Deep Convolutional Neural Networks
  4. The ASCO Post, 2014 -- Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography
  5. Summary of USPSTF Final Recommendation: Screening for Breast Cancer, 2024
  6. Diagnostic accuracy of digital breast tomosynthesis and digital mammography in women with dense or non-dense breast tissue: A systematic review and meta-analysis - PubMed
  7. Summary of USPSTF Final Recommendation: Screening for Breast Cancer
  8. Diagnostic accuracy of digital breast tomosynthesis and digital mammography in women with dense or non-dense breast tissue: A systematic review and meta-analysis - PubMed
  9. https://www.accessdata.fda.gov/cdrh_docs/pdf24/K240417.pdf

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