Clinical Report: Port-Site Metastasis Following Diagnostic Laparoscopy in Advanced Ovarian Cancer

Overview

This report presents a case of late-onset giant port-site metastasis (PSM) following diagnostic laparoscopy in a patient with advanced ovarian cancer. A systematic review indicates a wide variability in PSM incidence and identifies key risk factors associated with its occurrence.

Background

Ovarian cancer is the most lethal gynecological malignancy, with many patients diagnosed at advanced stages. Diagnostic laparoscopy is essential for assessing resectability and guiding treatment decisions, but it carries risks, including port-site metastases. Understanding the incidence and management of PSM is crucial for optimizing surgical approaches and patient outcomes.

Data Highlights

Key Findings

• PSM incidence varies widely from 1.18% to 46.7% based on detection methods.
• Advanced FIGO stage, large-volume ascites, and extensive peritoneal disease are significant risk factors for PSM.
• PSM does not independently affect overall survival but indicates aggressive disease biology.
• Routine port-site resection can control local disease but increases wound-related morbidity.
• Diagnostic laparoscopy remains a safe and cost-effective procedure when performed in specialized centers.

Clinical Implications

Clinicians should be aware of the risk factors for port-site metastasis when performing diagnostic laparoscopy in advanced ovarian cancer. The decision to perform routine port-site excision should consider the potential for increased morbidity without a clear survival benefit.

Conclusion

Port-site metastases following diagnostic laparoscopy are more common than previously recognized, yet they do not significantly impact prognosis. Careful management strategies are essential to balance the risks and benefits of surgical interventions.

Related Resources & Content

1. European Radiology, 2024 -- Revised Guidelines for Staging and Monitoring Ovarian Cancer
2. Discussion on the Article, 2025 -- Impact of Metastatic Locations and Metastasectomy on Prognosis in Colorectal Cancer
3. Comparison of Single-Incision Plus One-Port Laparoscopic Surgery, 2024 -- A Systematic Review and Meta-Analysis
4. Histopathological Evaluation for Identifying Colorectal Ovarian Micrometastases, 2025
5. ASCO Updates Guidelines on Neoadjuvant Chemotherapy in Advanced Ovarian Cancer, 2025
6. Frontiers, 2026 -- Port-Site Metastases After Diagnostic Laparoscopy in Advanced Ovarian Cancer
7. BMC Women's Health, 2024 -- Minimally Invasive Resection of Port-Site Metastasis
8. PubMed, 2023 -- Pathogenesis and Possible Consequences of Port-Site Metastasis
9. ASCO Updates Guidelines on Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
10. Frontiers | Port-Site Metastases After Diagnostic Laparoscopy in Advanced Ovarian Cancer: A Case Report and a Systematic Review of the Literature
11. The minimally invasive resection of port-site metastasis of ovarian cancer after laparoscopy with cutaneous integrity: a case report and literature review | BMC Women's Health | Full Text
12. Pathogenesis and Possible Consequences of Port-Site Metastasis in Gynecologic Oncology After Laparoscopic Procedures - PubMed