Postoperative delirium in elderly orthopedic patients: a narrative review of prevention and multidisciplinary nursing interventions - Report - MDSpire

Postoperative delirium in elderly orthopedic patients: a narrative review of prevention and multidisciplinary nursing interventions

  • By

  • Chen Wang

  • Chuanqiang Dai

  • Guifang Wu

  • Youshu Zhang

  • Yao Zhang

  • Yao Dong

  • June 30, 2026

  • 0 min

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Clinical Report: Preventing Postoperative Delirium in Older Orthopedic Surgery Patients

Overview

Postoperative delirium (POD) affects a significant proportion of elderly orthopedic patients, with rates ranging from 20% to 60%. This review highlights non-pharmacological strategies, particularly the eCASH bundle, which can reduce POD rates through multidisciplinary collaboration.

Background

POD is a common complication in older surgical patients, leading to prolonged hospital stays and increased treatment costs. Many cases remain undiagnosed, highlighting the importance of understanding POD mechanisms and implementing evidence-based interventions.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

  • POD occurs in 20–60% of elderly orthopedic patients but goes undiagnosed in over 70% of cases.
  • Neuroinflammation and neurotransmitter dysregulation are core mechanisms of POD.
  • Risk stratification tools can identify high-risk patients before surgery.
  • The eCASH bundle—Early mobilization, Cognitive stimulation, Adequate sleep, Social support, and Homelike environment—has been associated with reduced POD rates.
  • Multidisciplinary teamwork is more effective than single-discipline approaches in preventing POD.
  • Implementation barriers can be addressed with structured training and simple protocols.

Clinical Implications

Healthcare professionals should screen all postoperative patients aged 65 years and older for POD. For those identified as high-risk, activating the eCASH bundle with multidisciplinary coordination is suggested.

Conclusion

A strategy involving risk stratification, the eCASH bundle, and multidisciplinary collaboration is essential for addressing the incidence of POD in elderly orthopedic patients.

Related Resources & Content

  1. Conexiant, Conexiant, 2023 -- Preop Cognitive Impairment Tied to TKA Delirium
  2. BMC Psychiatry (Springer), BMC Psychiatry, 2025 -- Machine Learning-Based prediction models for postoperative delirium: a systematic review and Meta-Analysis
  3. BJS (British Journal of Surgery), BJS, 2023 -- Optimizing Perioperative Management for Surgical Patients in the Elderly Population
  4. Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials | The BMJ, The BMJ, 2025 -- Effectiveness of drug interventions to prevent delirium after surgery for older adults
  5. ESAIC, ESAIC, 2024 -- 2024 European Society of Anaesthesiology and Intensive Care guideline update
  6. Frontiers in Neurology — The effect of preoperative stellate ganglion block on postoperative delirium in elderly patients undergoing gastrointestinal oncologic surgery: protocol for a randomized, double-blind, sham-controlled trial
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  8. Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials | The BMJ
  9. Frontiers | Incidence and factors associated with postoperative delirium after primary total joint arthroplasty in older adults: a systematic review and meta-analysis

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