Biogenic Caralluma sinaica-derived silver nanoparticles as a synergistic antibacterial and osteoinductive nanoplatform for osteomyelitis management - Report - MDSpire

Biogenic Caralluma sinaica-derived silver nanoparticles as a synergistic antibacterial and osteoinductive nanoplatform for osteomyelitis management

  • By

  • Aldayel, Munirah F

  • Ali, Enas M

  • Abdallah, Basem M

  • May 11, 2026

  • 0 min

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Clinical Report: Silver Nanoparticles Derived from Biogenic Caralluma sinaica

Overview

This study presents a novel formulation of green phytosynthesized silver nanoparticles (CS-AgNPs) combined with plant extract for the treatment of osteomyelitis. The formulation demonstrated significant antibacterial and osteoinductive properties in a mouse model.

Background

Osteomyelitis is a challenging inflammatory bone disease often complicated by antibiotic resistance and inadequate immune responses. Current treatment options may not sufficiently address these issues, necessitating the exploration of innovative approaches. The development of multifunctional agents like CS-AgNPs could enhance treatment efficacy.

Data Highlights

ParameterResult
MIC against Staphylococcus aureusSignificantly reduced
MBC against Staphylococcus aureusSignificantly reduced
Cellular toxicityNo toxicity in vitro and in vivo
Osteocalcin positive osteoblastsIncreased in treated group
Collagen depositionIncreased in treated group

Key Findings

  • CS-AgNPs exhibited strong antibacterial potency against Staphylococcus aureus.
  • The hybrid formulation reduced MIC and MBC values significantly.
  • CS-AgNPs/PE showed no cellular toxicity in both in vitro and in vivo studies.
  • Local treatment with CS-AgNPs/PE inhibited bacterial burden and inflammatory response in osteomyelitis mice.
  • Immune-histochemical analysis revealed increased osteocalcin positive osteoblasts and collagen deposition in treated bones.

Clinical Implications

Further investigation into the clinical application of CS-AgNPs/PE may be warranted.

Conclusion

Continued research is necessary to validate these findings in clinical settings.

Related Resources & Content

  1. The analytical scientist, 2026 -- Gold Nanostars Take SERS Inside the Biofilm
  2. Drugs - Real World Outcomes, 2020 -- Clinical Application of Oritavancin in Osteomyelitis Management
  3. Frontiers in Immunology, 2026 -- Que/n-HA/PGCL microspheres orchestrate bone repair via context-dependent osteoimmune mechanisms
  4. IWGDF/IDSA Guidelines, 2023 -- Diagnosis and Treatment of Diabetes-Related Foot Infections
  5. ScienceDirect, 2024 -- The FRI classification – A new classification of fracture-related infections
  6. Archives of Toxicology — Modification of CuO Nanoparticles through Surface Carboxylation or PEGylation Reduces Cytotoxic Effects on Human Cells In Vitro While Preserving Antibacterial Activity
  7. Chronic Nonspinal Osteomyelitis in Adults: Consensus Recommendations on Percutaneous Bone Biopsies
  8. Single versus two-stage management of long-bone chronic osteomyelitis in adults: a systematic review and meta-analysis
  9. IWGDF/IDSA Guidelines on the Diagnosis and Treatment of Diabetes-Related Foot Infections
  10. The FRI classification – A new classification of fracture-related infections - ScienceDirect
  11. Outcomes and safety of antibiotic-loaded calcium sulfate beads in orthopaedics: A systematic review and meta-analysis - ScienceDirect
  12. Comparative effectiveness of silver-coated implants in periprosthetic infection prevention: A systematic review and meta-analysis - PMC
  13. Antibacterial Silver-Nanoparticle-Coated Stainless Steel Nails for Implant-Associated Osteomyelitis | ACS Applied Nano Materials

Original Source(s)

Biogenic Caralluma sinaica-derived silver nanoparticles as a synergistic antibacterial and osteoinductive nanoplatform for osteomyelitis management

  • by Aldayel, Munirah F, Ali, Enas M, Abdallah, Basem M

  • May 11, 2026

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