A scoping review of AI in the classification of oral cancer and oral potentially malignant disorders from visible-light photography - Report - MDSpire
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A Comprehensive Review of Artificial Intelligence Applications in Classifying Oral Cancer and Potentially Malignant Oral Disorders Using Visible-Light Imaging

  • By

  • Charles Goodmaker

  • Rishi Bhandari

  • Anwar Tappuni

  • Tuan D. Pham

  • August 22, 2026

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Clinical Report: AI Applications in Classifying Oral Cancer and OPMDs

Background

Oral cancer is a significant global health issue, with over 389,000 cases reported worldwide. The challenge of accurately diagnosing potentially malignant lesions, such as oral leukoplakia, necessitates innovative approaches to enhance early detection and management. AI technologies, particularly machine learning and deep learning, offer potential solutions for automating the classification of oral lesions.

Data Highlights

No numerical or trial data provided in the source material.

Key Findings

  • Oral cancer is the 16th most prevalent cancer globally, with significant morbidity and mortality.
  • Oral leukoplakia has a reported progression rate to oral squamous cell carcinoma of 7.2%.
  • Histopathological biopsy remains the gold standard for diagnosing oral lesions.
  • AI applications in dermatology have shown promise.
  • Machine learning and deep learning techniques, particularly convolutional neural networks, are pivotal in medical image classification.

Clinical Implications

The integration of AI in the classification of oral lesions could streamline diagnostic processes.

Conclusion

AI technologies present opportunities to enhance the classification and management of oral cancer and OPMDs.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. the pathologist, The Hidden Signals of Oral Cancer Risk, 2026 -- Title
  3. DIGITAL HEALTH, Visualization of artificial intelligence applications in oral disease diagnosis: A bibliometric analysis, 2026 -- Title
  4. Journal of the American Dental Association, Light-based adjuncts to determine the need for biopsy for early detection of oral squamous cell carcinoma and potentially malignant disorders: An evidence summary of a living systematic review, Version 2026 1.0, 2026 -- Title
  5. Recommendation: Oral Cancer: Screening | United States Preventive Services Taskforce, 2023 -- Title
  6. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial, 2023 -- Title
  7. Artificial Intelligence Helps Diagnose Oral Potentially Malignant Disorders: A Systematic Review and Meta-Analysis, 2023 -- Title
  8. Recommendation: Oral Cancer: Screening | United States Preventive Services Taskforce
  9. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial.
  10. Artificial Intelligence Helps Diagnose Oral Potentially Malignant Disorders: A Systematic Review and Meta-Analysis

Original Source(s)

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