HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion - Report - MDSpire
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HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion
Moderately Differentiated Squamous Cell Carcinoma of the Cervix Associated with HPV
Background
Cervical squamous cell carcinoma (CSCC) is a significant health concern, being the fourth most common cancer in women globally. Bladder invasion by CSCC is rare, occurring in only 5%-8% of cases, and often leads to misdiagnosis as primary urologic disease. Understanding the presentation and diagnostic challenges of CSCC is crucial for timely and appropriate treatment.
Data Highlights
No numerical or trial data available in the source material.
Key Findings
A 74-year-old woman presented with obstructive uropathy due to bladder invasion by CSCC.
Initial symptoms included anuria, bilateral hydronephrosis, and fever, leading to acute kidney injury.
Pathological confirmation of bladder invasion was achieved through transurethral biopsy showing invasive squamous cell carcinoma.
Immunohistochemistry revealed a CK7+/CK20−/P63+/p16+ profile, aiding in the diagnosis.
The patient was diagnosed with clinical FIGO stage IVB due to bladder invasion and suspected adrenal metastasis.
Early palliative urinary diversion provided temporary renal function improvement.
Clinical Implications
Healthcare providers should consider gynecologic malignancies in female patients presenting with unexplained urinary symptoms.
Conclusion
This case highlights the diagnostic complexities of CSCC presenting with urinary symptoms.
