Clinical Report: Visceral Fat Area and Lipid Profiles in Colorectal Cancer
Overview
Revise to clarify the relationship between high VFA/lipid levels and survival outcomes.
Background
Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide, with surgical resection being the primary treatment. Accurate preoperative risk stratification is crucial due to the variability in postoperative outcomes. This study addresses the role of metabolic factors, particularly visceral fat and lipid profiles, in predicting surgical risks and long-term survival in CRC patients.
Data Highlights
No significant differences in short-term complications were observed among the combined VFA/lipid groups (P > 0.05). However, patients with high VFA and high lipid levels demonstrated significantly better overall survival (OS) and recurrence-free survival (RFS) compared to those with low VFA and normal lipids (HR ≈ 0.50, P < 0.01).
Key Findings
High VFA (≥ 100 cm²) and dyslipidemia were assessed in 482 CRC patients undergoing radical surgery.
No significant short-term complications were noted across VFA/lipid groups.
Patients with both high VFA and high lipid levels had improved OS and RFS.
Age, TNM stage, and surgical approach were independent prognostic factors.
The study supports the 'obesity paradox' in advanced cancer patients.
Clinical Implications
The combination of VFA and lipid profiles can serve as a valuable preoperative tool for risk stratification in CRC patients. Clinicians should consider these metabolic indicators when assessing surgical risks and potential long-term outcomes.
Conclusion
Integrating VFA and lipid levels into preoperative assessments may enhance prognostic accuracy in CRC patients, potentially guiding clinical decision-making and improving patient outcomes.
