A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range - Report - MDSpire
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A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range
Clinical Report: Evaluating the Influence of Gonadotropin Dosage on Embryo Quality
Overview
This study analyzes the impact of gonadotropin dosage on embryo quality and pregnancy outcomes in IVF patients.
Background
Infertility affects approximately 18% of couples in China, making assisted reproductive technology (ART) crucial for many. Controlled ovarian stimulation (COS) using gonadotropins is a key component of ART, influencing the success rates of in vitro fertilization (IVF). Understanding the optimal gonadotropin dosage is essential for improving embryo quality and pregnancy outcomes.
Data Highlights
Gn Dose Group
Excellent Embryos Rate
Clinical Pregnancy Rate
Live Birth Rate
Abortion Rate
Group 1 (≤1,550 IU)
Higher
Higher
Higher
Lower
Group 2 (1,550 IU < Gn ≤2,194 IU)
Moderate
Moderate
Moderate
Moderate
Group 3 (2,194 IU < Gn ≤2,700 IU)
Lower
Lower
Lower
Higher
Group 4 (>2,700 IU)
Lowest
Lowest
Lowest
Highest
Key Findings
Group 1 had significantly higher rates of excellent embryos compared to groups 2, 3, and 4.
Clinical pregnancy and live birth rates were significantly higher in group 1.
Abortion rates were significantly lower in group 1 compared to other groups.
Blastocyst formation rates were higher in groups 1 and 2 than in groups 3 and 4.
Total gonadotropin dosage was identified as an independent risk factor for positive HCG rates, abortion, and live birth.
Increases in gonadotropin dosage above certain thresholds resulted in decreased rates of blastocyst formation and live births.
Clinical Implications
Monitoring gonadotropin dosage may help mitigate risks associated with both low and high gonadotropin levels.
Conclusion
The study highlights the significant influence of gonadotropin dosage on embryo quality and pregnancy outcomes.
