Video: The Ultimate in Translational Medicine – with Harold Keer

Power List 2026 honoree Harold Keer traces oncology’s transformation – and considers what it will take to turn today’s “abundance of riches” into better patient outcomes

November 6, 2026
1 min

The Medicine Maker

Overview

Harold Keer, Chief Medical Officer at Taiho Oncology, describes industry as a route for translating discoveries into medicines at scale. He reflects on changes in oncology drug development, persistent challenges in selectively targeting malignant cells, and the need to keep patients central to clinical development.

Background

Keer initially envisioned an academic career combining patient care, teaching, and laboratory research, but pursued drug development in industry. The article describes an evolution from cytotoxic chemotherapy to targeted therapies, monoclonal antibodies, immunotherapies, bispecific antibodies, and antibody-drug conjugates. It also notes that targets once considered undruggable, including RAS, have become active areas of development. Despite these advances, the challenge of destroying malignant cells while sparing healthy tissue remains.

Data Highlights

The source article is an interview and provides no numerical trial or clinical outcome data.

Key Findings

Keer characterizes the development of medicines in industry as “the ultimate translational medicine,” because it can scale discoveries for patients.
Oncology development has expanded beyond cytotoxic chemotherapy to include targeted therapies, monoclonal antibodies, immunotherapies, bispecific antibodies, and antibody-drug conjugates.
RAS, previously described as an “undruggable” target, is now a competitive area of drug development.
The fundamental challenge identified in the article is killing malignant cells while sparing healthy tissue.
Keer discusses why promising cancer programs can fail and considers the promise of emerging modalities alongside the possibility of “irrational exuberance.”
Keer identifies advancing Taiho’s newly acquired ADC technology into clinical development as unfinished work.

Clinical Implications

The interview emphasizes keeping patients at the center of clinical development and recognizes that compelling cancer programs may still fail. It does not provide specific treatment recommendations or clinical outcome data.

Conclusion

Keer’s account links oncology’s expanding therapeutic toolkit with the continuing challenge of translating discoveries into medicines while maintaining a focus on patients. His stated priority is to advance Taiho’s acquired ADC technology toward clinical testing.