Efficacy and Safety of Ultrasound-Guided Intra-Articular Injection of Low-Molecular-Weight Peptides from Hydrolyzed Collagen in Patients with Osteoarthritis of the First Carpometacarpal Joint

Overview

This study evaluates the efficacy and safety of ultrasound-guided intra-articular injections of low-molecular-weight peptides derived from hydrolyzed collagen in patients with symptomatic osteoarthritis of the first carpometacarpal joint. The primary endpoint is the change in pain during activity after three months, with secondary outcomes including pain at rest and hand function.

Background

Osteoarthritis of the first carpometacarpal joint is a prevalent condition that leads to significant pain and functional impairment, particularly in middle-aged and older adults. Current treatment options include conservative measures and various injectable therapies.

Data Highlights

This study is a prospective single-arm interventional trial designed to assess the effects of low-molecular-weight peptides on pain and function in patients with CMC-1 OA over a follow-up period of up to six months.

Key Findings

• The primary endpoint is the change in pain during activity after 3 months.
• Secondary outcomes include pain at rest, hand disability, grip and key pinch strength, and patient-reported improvement.
• The study will also evaluate treatment-related adverse events and ultrasonographic findings.
• Baseline clinical and ultrasonographic patterns may be explored for their association with clinical and imaging responses.

Clinical Implications

The findings from this study may inform clinicians about the potential role of low-molecular-weight peptides as a treatment option for patients with symptomatic CMC-1 osteoarthritis.

Conclusion

The study aims to provide evidence on the efficacy and safety of a new injectable treatment for CMC-1 osteoarthritis. Further results will clarify its role.

Related Resources & Content

1. Clinical Rheumatology, 2020 -- Evaluation of Short-Term Outcomes from Single-Dose Intra-Articular Peptide Compared to Hyaluronic Acid and Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Randomized Trial
2. Knee Surgery, Sports Traumatology, Arthroscopy, 2008 -- Prospective Multicenter Study Assessing the Safety and Effectiveness of Hylan G-F 20 in Patients with Knee Osteoarthritis Experiencing Pain After Arthroscopic Meniscectomy
3. Therapeutic Infiltration Techniques in Cartilage Surgical Interventions, 2023 -- Therapeutic Infiltration Techniques in Cartilage Surgical Interventions
4. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee
5. Knee Surgery, Sports Traumatology, Arthroscopy — Hyaluronic Acid Administration Post-Knee Arthroscopy: Findings from a Two-Year Investigation
6. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee - PMC
7. Efficacy of Intra-Articular Corticosteroid Injection for Nonsurgical Management of Trapeziometacarpal Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - ScienceDirect
8. Accuracy of ultrasound-guided versus palpation-based carpometacarpal joint injections: A randomized pilot study in cadavers - PMC