The Association of Physical Function With Psychosocial Patient-Reported Outcomes in People With Systemic Lupus Erythematosus - Report - MDSpire
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The Relationship Between Physical Function and Psychosocial Outcomes Reported by Patients with Systemic Lupus Erythematosus

  • By

  • Mrinalini Dey

  • Jessica Fitzpatrick

  • Maria Dall'Era

  • Charmayne Dunlop-Thomas

  • Courtney Hoge

  • S. Sam Lim

  • Patricia P. Katz

  • Jinoos Yazdany

  • Laura C. Plantinga

  • May 3, 2026

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Clinical Report: The Relationship Between Physical Function and Psychosocial Outcomes in SLE

Overview

This study investigates the associations between psychosocial factors and physical function in patients with systemic lupus erythematosus (SLE).

Background

Physical disability is prevalent in individuals with systemic lupus erythematosus (SLE), affecting their quality of life and increasing healthcare costs. Approximately 30% of SLE patients are considered frail, and over half exhibit poor physical performance. Understanding the interplay between physical function and psychosocial factors is crucial.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • Physical function is a core outcome in SLE and significantly influences disability.
  • Psychosocial factors such as fatigue, depression, perceived stress, coping, and self-efficacy are associated with physical function.
  • The study utilized two diverse cohorts to enhance the generalizability of findings related to psychosocial factors and physical function.
  • Patient-reported outcome measures (PROMs) are essential for capturing the lived experiences of SLE patients.
  • Further studies are needed to include diverse populations to understand the factors affecting physical function in SLE.

Clinical Implications

Incorporating patient-reported outcomes into clinical practice can provide insights into the psychosocial factors affecting physical function in SLE patients.

Conclusion

The study highlights the importance of understanding psychosocial factors in relation to physical function in SLE.

Related Resources & Content

  1. Arthritis Care & Research, Neighborhood Socioeconomic Status and Short-Term Functional Outcomes in Systemic Lupus Erythematosus, 2021
  2. Clinical Rheumatology, The Role of Empowerment in Promoting Health-Enhancing Physical Activity Among Rheumatoid Arthritis Patients with Limited Physical Function: A Cross-Sectional Analysis, 2021
  3. Clinical Rheumatology, Impact of Clinical Manifestations on Life Quality and Satisfaction in Patients with Systemic Lupus Erythematosus, 2010
  4. Frontiers in Digital Health, Using objective measures of physical activity, sleep, and breathing for disease profiling of patients with systemic lupus erythematosus and Sjögren's disease, 2026
  5. EULAR recommendations for a core dataset to support clinical care and translational and observational research in systemic lupus erythematosus, 2025
  6. A randomized controlled trial of a lifestyle intervention on wellbeing in patients with systemic lupus erythematosus: Results from 'Living well with lupus', 2023
  7. EULAR recommendations for a core dataset to support clinical care and translational and observational research in systemic lupus erythematosus - ScienceDirect
  8. A randomized controlled trial of a lifestyle intervention on wellbeing in patients with systemic lupus erythematosus: Results from "Living well with lupus" - PubMed

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