Integration of miRNA profiles and clinical data for early risk assessment of bronchopulmonary dysplasia in VLBW and ELBW newborn infants: a discovery study - Report - MDSpire

Integration of miRNA profiles and clinical data for early risk assessment of bronchopulmonary dysplasia in VLBW and ELBW newborn infants: a discovery study

  • By

  • Iskander Isgandarov

  • Arailym Abilbayeva

  • Anel Tarabayeva

  • Dinara Yelyubayeva

  • Nishankul Bozhbanbayeva

  • Ingkar Okhas

  • Nuray Shaktay

  • Dana Yerbolat

  • Kristina Kovaleva

  • Zhanar Akhmetova

  • Zulfiya Kachiyeva

  • Aibek Smagul

  • July 6, 2026

  • 0 min

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Clinical Report: Combining miRNA Profiles with Clinical Data for Early Risk Evaluation of Bronchopulmonary Dysplasia

Overview

This study identifies candidate miRNA markers in blood samples for early risk assessment of bronchopulmonary dysplasia (BPD) in very low birth weight infants. A predictive model combining miRNA and clinical data achieved a high AUC of 0.940.

Background

Bronchopulmonary dysplasia (BPD) is a serious complication of prematurity, particularly affecting infants with very low birth weights. Early prediction of BPD is challenging due to reliance on retrospective diagnostic criteria.

Data Highlights

miRNAAdjusted p-value
hsa-let-7b-5p< 0.05
hsa-miR-27a-3p< 0.05
hsa-let-7c-5p< 0.05
hsa-miR-182-5p< 0.05

Key Findings

  • Five miRNAs showed significantly higher levels in infants who developed BPD.
  • The predictive model integrating miRNA and clinical data achieved an adjusted LOOCV-AUC of 0.940.
  • The model outperformed one based solely on clinical data, which had an AUC of 0.719.
  • No significant associations were found between the candidate miRNAs and systemic inflammatory parameters.
  • Four miRNAs were selected based on statistical significance and regression stability criteria.

Clinical Implications

Further validation is necessary before clinical application.

Conclusion

The study demonstrates a combined model using miRNA and clinical data for early BPD risk evaluation.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity
  2. Frontiers in Pediatrics, 2026 -- A nomogram for predicting the risk of bronchopulmonary dysplasia in preterm infants: a prospective multicenter study
  3. The Journal of Infectious Diseases -- Transcriptomic Biomarkers Associated With Microbiological Etiology and Disease Severity in Childhood Pneumonia
  4. Toward a Harmonized Bronchopulmonary Dysplasia Definition: An International Delphi Process | Pediatrics | American Academy of Pediatrics
  5. Survival without bronchopulmonary dysplasia in extremely preterm infants: an external, population-based validation, comparison and optimisation study of recent prediction models at baseline
  6. Ophthalmology Management — Study Shows Retinal Scans Predict Neonatal Lung Disease
  7. Toward a Harmonized Bronchopulmonary Dysplasia Definition: An International Delphi Process | Pediatrics | American Academy of Pediatrics
  8. Survival without bronchopulmonary dysplasia in extremely preterm infants: an external, population-based validation, comparison and optimisation study of recent prediction models at baseline
  9. Diagnostic potential of serum miR-197 and IL-18 levels in predicting bronchopulmonary dysplasia: a prospective cohort study - PubMed

Original Source(s)

Integration of miRNA profiles and clinical data for early risk assessment of bronchopulmonary dysplasia in VLBW and ELBW newborn infants: a discovery study

  • by Iskander Isgandarov, Arailym Abilbayeva, Anel Tarabayeva, Dinara Yelyubayeva, Nishankul Bozhbanbayeva, Ingkar Okhas, Nuray Shaktay, Dana Yerbolat, Kristina Kovaleva, Zhanar Akhmetova, Zulfiya Kachiyeva, Aibek Smagul

  • July 6, 2026

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