Age-related changes in central corneal thickness and their association with ocular biometric parameters in children - Report - MDSpire

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children

  • By

  • Qing Yuan

  • Yawen Bai

  • Zhe Su

  • Ying Zou

  • Yan Lu

  • May 22, 2026

  • 0 min

Share

Clinical Report: Impact of Age on Central Corneal Thickness in Children

Overview

This study investigates age-related changes in central corneal thickness (CCT) among pediatric patients and its correlation with ocular biometric parameters. Findings indicate that CCT increases with age in children aged 3–12 years.

Background

Central corneal thickness (CCT) is a critical parameter in ophthalmic assessments. This study addresses the limited research on CCT in pediatric populations.

Data Highlights

ParameterMean ValueSignificance
CCT (Myopic)548.77 ± 34.37 μmp = 0.021
CCT (Non-myopic)554.20 ± 31.29 μm
Correlation with Ager = 0.150p < 0.001
Correlation with ALr = 0.121p = 0.001
Correlation with ACDr = 0.079p = 0.026
Correlation with Kmr = -0.239p < 0.001

Key Findings

  • The mean age of participants was 9.5 ± 3.1 years.
  • CCT showed a significant positive correlation with age, AL, and ACD.
  • Myopic eyes had a thinner CCT compared to non-myopic eyes.
  • CCT increased significantly over one year in children aged 3–12 years.
  • No significant correlation was found between CCT and lens thickness.

Clinical Implications

The findings emphasize the importance of understanding the relationship between CCT and other ocular parameters.

Conclusion

CCT increases with age in children aged 3–12 years and stabilizes after 13 years.

Related Resources & Content

  1. Frontiers in Pediatrics, 2026 -- Age-related changes in lens thickness in children aged 3-17 years and its association with myopia and ocular biological parameters: a cross-sectional and longitudinal study
  2. Frontiers in Medicine, 2026 -- The relationship between corneal biomechanics and endothelial morphology: evidence from a Saudi cohort
  3. Optometric Management, 2006 -- Pachymetry: The New Standard of Care in Glaucoma
  4. Ophthalmology Management, 2003 -- IOP: The Corneal Thickness Factor
  5. Glaucoma in Children - American Association for Pediatric Ophthalmology and Strabismus
  6. Journal of Optometry, 2025 -- Sex-specific CCT trajectories in children
  7. Eye, 2025 -- Growth hormone therapy and ocular biometry in paediatric growth hormone deficiency: a systematic review and meta-analysis
  8. Glaucoma in Children - American Association for Pediatric Ophthalmology and Strabismus
  9. Journal of Optometry 18 (2025) 100537
  10. Growth hormone therapy and ocular biometry in paediatric growth hormone deficiency: a systematic review and meta-analysis | Eye

Original Source(s)

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children

  • by Qing Yuan, Yawen Bai, Zhe Su, Ying Zou, Yan Lu

  • May 22, 2026

Related Content

Beyond the Diopter: Evolving Your Framework for Refractive Surgery Planning

Corneal health, axial length, and long-term ocular preservation are helpful guides for every refractive conversation

Astigmatism Up After COVID Restrictions

Researchers identified delayed corneal changes in schoolchildren that emerged after myopia rates had already increased during the pandemic.

Could Red-Light Therapy Change Myopia Care? 

Across 28 trials, pediatric patients receiving therapy had less myopia progression over 12 months, though long-term risks remain under study.