Clinical Report: Exploring the Potential of Cerebellar iTBS for Balance in CA

Overview

This pilot study assessed the effects of 50 Hz cerebellar intermittent theta burst stimulation (iTBS) on static balance in patients with cerebellar ataxia (CA). Results indicated improvements in postural stability immediately post-intervention, although these effects were not sustained after six weeks.

Background

Cerebellar ataxia (CA) is characterized by balance impairment and gait instability due to cerebellar dysfunction. The cerebellum is crucial for motor coordination and postural balance, integrating sensory feedback. Understanding potential therapeutic interventions like iTBS is essential for improving patient outcomes in CA.

Data Highlights

Key Findings

• iTBS was administered over five consecutive days for 8 minutes per session.
• Improvements in balance were observed immediately post-intervention (V1) compared to baseline (V0).
• Improvements in balance were not sustained at the 6-week follow-up (V2).
• Dizziness was reported as a mild–moderate adverse event in 50% of participants.
• Functional near-infrared spectroscopy (fNIRS) indicated cortical engagement during cognitive-motor tasks.

Clinical Implications

Clinicians should be aware of the reported adverse events such as dizziness.

Conclusion

Cerebellar iTBS appears to be a well-tolerated intervention that can enhance postural stability in patients with cerebellar ataxia.

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