Clinical Report: A Sequential Approach Utilizing Initial Radiofrequency Ablation

Overview

This study evaluates the clinical outcomes of endoscopic papillectomy (EP) and the feasibility of a sequential radiofrequency ablation (RFA)-first strategy for complex ampullary tumors.

Background

Ampullary tumors are rare but pose significant clinical challenges due to their potential for malignant transformation and the complexities involved in their management. Traditionally treated with surgical approaches, endoscopic papillectomy has emerged as a less invasive first-line option, although it carries risks of complications, particularly with larger tumors.

Data Highlights

Key Findings

• 123 out of 132 patients underwent endoscopic papillectomy (EP).
• 9 patients received radiofrequency ablation (RFA) as initial treatment due to complex tumor characteristics.
• The overall short-term clinical success rate was 96.6% across all patients.
• Adverse events occurred in 20.5% of patients, with significant risk factors identified.
• No significant difference in adverse events was found between RFA and non-RFA groups (p = 0.719).

Clinical Implications

Clinicians should consider tumor size and characteristics when determining treatment strategies.

Conclusion

Further studies are needed to assess long-term outcomes and complications.

Related Resources & Content

1. European Society of Gastrointestinal Endoscopy, ESGE Guidelines, 2021 -- Endoscopic papillectomy for ampullary lesions
2. Endoscopic papillectomy for ampullary lesions: pooled analysis with meta-regression analysis of outcomes - PubMed, 2026
3. Combination of Endoscopic Vacuum Therapy (eVAC) and Continuous Perianastomotic Irrigation to Mitigate Anastomotic Leakage Following Surgical Ampullectomy
4. Frontiers in Endocrinology — Ultrasound-guided radiofrequency ablation for recurrent contralateral tumor that developed after initial surgery for papillary thyroid carcinoma
5. Frontiers in Surgery — Radiofrequency Ablation (RFA) of Papillary Thyroid Microcarcinoma (PTMC)
6. Surgical Endoscopy — Initial Outcomes of Laparoscopic Ablation for Hepatic Malignancies at a High-Volume Scandinavian HPB Center
7. 20605 429..448
8. Endoscopic papillectomy for ampullary lesions: pooled analysis with meta-regression analysis of outcomes - PubMed
9. Thieme E-Journals - Endoscopy International Open / Full Text