Comparative efficacy of early exercise interventions for recovery outcomes after total knee arthroplasty: a systematic review and network meta-analysis - Report - MDSpire

Comparative efficacy of early exercise interventions for recovery outcomes after total knee arthroplasty: a systematic review and network meta-analysis

  • By

  • Xinyue Yan

  • PinMei Li

  • Jia Li

  • Liting Song

  • Jiapeng Jing

  • Xiaochen Fu

  • Zhuo Xu

  • July 17, 2026

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Clinical Report: Effectiveness of Early Exercise Regimens on Recovery Following Total Knee Arthroplasty

Overview

This systematic review and network meta-analysis evaluated the effectiveness of early exercise interventions initiated within three days post-total knee arthroplasty (TKA) on pain relief, joint function, and range of motion.

Background

Total knee arthroplasty (TKA) is a common procedure for patients with severe knee osteoarthritis, aimed at alleviating pain and restoring function. Early rehabilitation is critical for optimizing recovery.

Data Highlights

InterventionPain Relief (SMD)WOMAC Improvement (SMD)ROM Improvement (SMD)SUCRA (%)
Functional Training-4.23-1.51N/A100
Resistance Training-1.57N/A1.9185.8
Intelligence-Assisted TrainingN/A-1.352.2194.7

Key Findings

  • 32 randomized controlled trials (RCTs) involving 1,871 patients were included in the analysis.
  • Functional training showed the highest efficacy for pain relief with a standardized mean difference (SMD) of -4.23.
  • Intelligence-assisted training and resistance training had the highest ranking probabilities for improving range of motion (ROM).
  • Evidence certainty was moderate for pain relief and low for WOMAC and ROM improvements.
  • Functional training and intelligence-assisted training provided significant improvements in functional status as measured by WOMAC.

Clinical Implications

Clinicians should consider incorporating functional training, intelligence-assisted training, and resistance training into early rehabilitation protocols for TKA patients. Tailoring these interventions based on individual patient needs and rehabilitation goals may enhance recovery outcomes.

Conclusion

Functional training, intelligence-assisted training, and resistance training appeared to be effective early exercise strategies after TKA.

Related Resources & Content

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  2. Effectiveness and Economic Impact of Physiotherapy After Total Knee Arthroplasty: A Comprehensive Review and Meta-Analysis
  3. Postoperative Trends in Knee Extensor Strength Following Total Knee Arthroplasty: A Systematic Review with Meta-Analysis and Meta-Regression
  4. DIGITAL HEALTH — Continuous preoperative activity patterns measured by wearable sensors are associated with recovery after total knee arthroplasty
  5. Frontiers in Medicine — Effectiveness of strength-oriented rehabilitation interventions as a non-pharmacologic rehabilitation strategy for knee function after anterior cruciate ligament reconstruction: a three-level meta-analysis
  6. NICE Guidelines on Joint Replacement
  7. ERAS Society Recommendations
  8. AAHKS Outpatient Position Statement
  9. Frontiers | Comparative efficacy of early exercise interventions for recovery outcomes after total knee arthroplasty: a systematic review and network meta-analysis
  10. Reducing the length of hospital stay for patients undergoing primary total knee arthroplasty by application of enhanced recovery after surgery (ERAS) pathway: a multicenter, prospective, randomized controlled trial
  11. Total knee arthroplasty: does ultra-early physical therapy improve functional outcomes and reduce length of stay? A retrospective cohort study - PMC
  12. Continuous Passive Motion After Total Knee Arthroplasty: A Systematic Review and Meta-analysis of Associated Effects on Clinical Outcomes - ScienceDirect
  13. Quiet Knee Rehabilitation Protocol After Primary Total Knee Arthroplasty Is Associated With Lower Opioid Exposure and No Added Risks: A Retrospective Cohort Study - ScienceDirect

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