Effects of digital health interventions on anxiety, depression, and quality of life in colorectal cancer patients: a meta-analysis of randomized controlled trials - Report - MDSpire

Effects of digital health interventions on anxiety, depression, and quality of life in colorectal cancer patients: a meta-analysis of randomized controlled trials

  • By

  • Mei-Ying Song

  • Min Li

  • Ling Tu

  • Jie Yang

  • June 2, 2026

  • 0 min

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Clinical Report: Impact of Digital Health Solutions on Anxiety and Depression in CRC

Overview

This meta-analysis evaluates the effects of digital health interventions on anxiety, depression, and quality of life among colorectal cancer (CRC) patients. The findings suggest that these interventions may significantly reduce anxiety and depression while improving quality of life, although the evidence is of low certainty.

Background

Colorectal cancer (CRC) is a major global health issue, with high rates of anxiety and depression among patients, which can severely impact their quality of life and treatment adherence. Traditional psychological support is often inaccessible, highlighting the need for alternative solutions. Digital health interventions have emerged as a promising approach to address these psychological challenges in CRC patients.

Data Highlights

OutcomeStandardized Mean Difference (SMD)95% Confidence Interval (CI)Evidence Certainty
Anxiety-0.90-1.59 to -0.2293%Low
Depression-0.93-1.64 to -0.2194%Low
Quality of Life0.780.19 to 1.3696%Low

Key Findings

  • Digital health interventions are associated with a significant reduction in anxiety among CRC patients.
  • These interventions also lead to a notable decrease in depression levels.
  • Quality of life improvements were observed in patients receiving digital health interventions.
  • The evidence supporting these findings is characterized by low certainty due to high heterogeneity among studies.
  • Further high-quality randomized controlled trials are necessary to confirm these results.

Clinical Implications

Healthcare providers should consider integrating digital health interventions into the supportive care plans for CRC patients to address psychological symptoms. Given the barriers to traditional psychological support, these digital solutions may offer a more accessible and effective means of improving mental health and quality of life.

Conclusion

Digital health interventions show promise in alleviating anxiety and depression while enhancing quality of life for CRC patients. However, the low certainty of evidence necessitates further research to validate these findings.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Impact of Depression and Anxiety on Mortality in Colorectal Cancer: A Systematic Review and Meta-Analysis of Univariate and Multivariate Findings
  2. Frontiers in Oncology, 2026 -- Effects of home-based exercise on anxiety, depression, cancer-related fatigue, and quality of life in colorectal cancer patients: a meta-analysis of randomized controlled trials
  3. npj Digital Medicine, 2025 -- Comprehensive Review and Meta-Analysis of Digital Health Solutions for Mental Well-Being in Cancer Patients and Survivors
  4. NCCN Guidelines® Insights: Distress Management, Version 1.2026 - PubMed
  5. Frontiers | Effects of digital health interventions on anxiety, depression, and quality of life in colorectal cancer patients: a meta-analysis of randomized controlled trials
  6. npj Digital Medicine — Evaluating the Impact of Digital Health Interventions on Patient-Reported Outcomes in Perioperative Care: A Network Meta-Analysis
  7. NCCN Guidelines® Insights: Distress Management, Version 1.2026 - PubMed
  8. Frontiers | Effects of digital health interventions on anxiety, depression, and quality of life in colorectal cancer patients: a meta-analysis of randomized controlled trials
  9. Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment | Oncology | JAMA | JAMA Network

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