Hair cortisol as psychotherapy process parameter – an inpatient pediatric psychosomatic study - Report - MDSpire

Hair cortisol as psychotherapy process parameter – an inpatient pediatric psychosomatic study

  • By

  • Tim Botschek

  • Anna Röhlich

  • Burkhard Brosig

  • July 7, 2026

  • 0 min

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Cortisol Levels in Hair as a Measure of Psychotherapy Progress

Overview

This study evaluates the efficacy of inpatient pediatric psychosomatic therapy by measuring hair cortisol concentration (HCC) alongside psychological outcomes. Significant improvements in stress, depressive symptoms, and family functioning were observed, with HCC decreasing from admission to discharge and remaining stable at follow-ups.

Background

Pediatric psychosomatic therapy is crucial for addressing mental disorders in children and adolescents, yet empirical research in this area is limited. Understanding both psychological and biological markers, such as HCC, can provide a more comprehensive view of treatment outcomes. This study aims to fill the gap by integrating biological data into the assessment of therapy outcomes.

Data Highlights

MeasurementTime PointResult
HCCAdmissionHigh
HCCDischargeSignificantly decreased
Psychological SymptomsFollow-ups (3 & 6 months)Stable improvements

Key Findings

  • Significant improvements in perceived stress and depressive symptoms during inpatient treatment.
  • Family functioning and internalizing symptoms also showed marked improvement.
  • HCC decreased significantly from admission to discharge.
  • Improvements in psychological outcomes remained stable at three- and six-month follow-ups.
  • Transient increases in depressive symptoms and family problems were noted post-discharge.

Clinical Implications

The findings indicate that biological markers like HCC can provide additional insights into treatment progress in pediatric psychosomatic therapy.

Conclusion

This study highlights the importance of incorporating biological markers into treatment evaluations.

Related Resources & Content

  1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Cortisone Levels in Hair and Their Association with Metabolic Syndrome: More Significant Connections in Younger Adults Compared to Older Individuals
  2. Intensive Care Medicine, 2019 -- Assessment of the Hypothalamus-Pituitary-Adrenal Axis in Pediatric Critical Illness: Prognostic Implications and the Role of Corticosteroid Therapy in a Prospective Observational Study
  3. Archives of Toxicology, 2024 -- Increased levels of paracetamol correlate with higher glucocorticoid levels in hair: insights from a large study of young adults
  4. Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial | Translational Psychiatry
  5. The Journal of Clinical Endocrinology & Metabolism — Advancements in the Treatment Approaches for Classic Congenital Adrenal Hyperplasia Resulting from 21-Hydroxylase Deficiency
  6. Guidelines for Treatment of Depressive Disorders in Children and Adolescents
  7. Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial | Translational Psychiatry
  8. Hair cortisol measurement: A systematic review of current practices and a proposed checklist for reporting standards - ScienceDirect

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