Diagnosis and treatment of breast cancer metastasis to thyroid: a case report and literature review - Report - MDSpire

Diagnosis and treatment of breast cancer metastasis to thyroid: a case report and literature review

  • By

  • TaiXu Jiang

  • YueNan Zheng

  • HongShi Shi

  • Liang He

  • MoFei Wang

  • May 25, 2026

  • 0 min

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Clinical Report: Evaluation and Management of Thyroid Metastasis from Breast Cancer

Overview

This report presents a rare case of thyroid metastasis from breast cancer occurring 16 years post-diagnosis. It emphasizes the importance of early identification and diagnosis to improve patient prognosis.

Background

Thyroid metastasis from breast cancer is infrequent, accounting for only 7.8% of thyroid metastatic cases. Due to non-specific symptoms and long intervals between primary cancer diagnosis and thyroid metastasis, it is often misdiagnosed, delaying treatment. Understanding this condition is crucial for clinicians to enhance diagnostic accuracy and patient outcomes.

Data Highlights

No numerical or trial data available in the article.

Key Findings

  • Thyroid metastatic cancer (TMC) has an incidence of only 0.36%.
  • Breast cancer is a rare origin for thyroid metastasis, representing 7.8% of cases.
  • The patient in this case report was diagnosed with breast cancer 16 years prior to thyroid metastasis.
  • Fine-needle aspiration biopsy (FNAB) is recommended for diagnosis, although the patient in this case refused it.
  • Postoperative pathology confirmed the thyroid cancer originated from breast cancer.
  • Multidisciplinary consultation is essential for managing thyroid metastasis from breast cancer.

Clinical Implications

Clinicians should maintain a high index of suspicion for thyroid nodules in patients with a history of breast cancer. Early diagnosis through FNAB and immunohistochemistry is critical for effective management.

Conclusion

Breast cancer metastasis to the thyroid is a rare but significant clinical scenario. Awareness and timely intervention are key to improving patient outcomes.

Related Resources & Content

  1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Evaluating the Diagnostic Performance of Thyroglobulin in Fine-Needle Aspiration Washout of Lymph Nodes: A Comprehensive Review and Meta-Analysis
  2. Metastatic Involvement of the Bowel in Undifferentiated Thyroid Carcinoma: A Case Study and Review of Existing Literature, 2025
  3. Association of Multifocal Papillary Thyroid Cancer and Hashimoto's Thyroiditis with Increased Risk of Lymph Node Metastasis, 2013
  4. Frontiers in Oncology, 2026 -- Synchronous metastatic differentiated high-grade thyroid carcinoma in lymph node from classic papillary thyroid carcinoma: a case report and literature review
  5. Metastasis to the Thyroid Gland: A Critical Review - PMC, 2023
  6. Metastasis to the Thyroid Gland: A Critical Review
  7. The Novel Marker GATA3 is Significantly More Sensitive Than Traditional Markers
  8. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, staging and treatment of patients with metastatic breast cancer
  9. Receptor Discordance in Metastatic Breast Cancer; a review of clinical and genetic subtype alterations from primary to metastatic disease | Breast Cancer Research and Treatment | Springer Nature Link
  10. HER2 Testing in Breast Cancer -… | College of American Pathologists
  11. Systemic Treatment of Patients With Metastatic Breast Cancer: ASCO Resource–Stratified Guideline Q and A - PMC
  12. Frontiers | Thyroid metastases from breast cancer: a case report and brief literature review

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