CAA Use Tied to Higher Arthroplasty Risk - Report - MDSpire

CAA Use Tied to Higher Arthroplasty Risk

In a UK cohort, patients with osteoarthritis who initiated centrally acting analgesics had a higher hazard of knee or hip replacement than those who initiated SSRIs, though residual confounding by pain severity remains a key limitation.

  • By

  • Andrea Surnit

  • June 1, 2026

  • 6 min

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CAA Use Tied to Higher Arthroplasty Risk

Overview

A population-based cohort study found that patients with knee or hip osteoarthritis who initiated centrally acting analgesics (CAA) had a significantly higher risk of total joint arthroplasty compared to those who initiated selective serotonin reuptake inhibitors (SSRIs).

Background

The management of knee and hip osteoarthritis is critical as it significantly impacts patient quality of life and may lead to surgical interventions such as joint replacement. Understanding the implications of different analgesic treatments on the progression of osteoarthritis is essential.

Data Highlights

GroupPatientsJoint Replacement EventsHazard Ratio (HR)
Centrally Acting Analgesics11,734617 (5.3%)1.81 (95% CI 1.59–2.07)
SSRIs11,734327 (2.8%)1.00

Key Findings

  • Centrally acting analgesic initiation was associated with an 81% higher hazard of knee or hip replacement compared to SSRIs.
  • Over a median follow-up of 9.5 years, 5.3% of patients on CAAs underwent joint replacement versus 2.8% on SSRIs.
  • In a subgroup with both osteoarthritis and depression, the hazard was 59% higher for CAA initiation.
  • Tricyclic antidepressants and gabapentinoids were associated with a 34% and 50% higher hazard of joint replacement, respectively.

Clinical Implications

Clinicians should be aware of the increased risk of joint replacement associated with the use of centrally acting analgesics in patients with osteoarthritis.

Conclusion

The study's findings suggest that centrally acting analgesics do not provide a protective effect against joint replacement in osteoarthritis patients.

Related Resources & Content

  1. Wang Z, et al., BMC Medicine, 2026 -- Associations of centrally acting analgesic use with total joint arthroplasty compared to selective serotonin reuptake inhibitor among osteoarthritis patients in a large prospective cohort
  2. Factors Contributing to Mechanical Failures in Total Hip Arthroplasties, Archives of Orthopaedic and Trauma Surgery, 2022
  3. Uncemented total knee arthroplasty is associated with higher complication rates: a propensity-matched retrospective study, Archives of Orthopaedic and Trauma Surgery, 2025
  4. Septic Arthritis Following Arthroscopic Surgery: Contemporary Diagnostic and Treatment Approaches, Knee Surgery, Sports Traumatology, Arthroscopy, 2021
  5. Recommendations | Osteoarthritis in over 16s: diagnosis and management | Guidance | NICE, 2022
  6. Guidelines for Resuming Athletic Activities Following Total Hip Arthroplasty Are Evolving Due to Advancements in Implant Technology
  7. Associations of centrally acting analgesic use with total joint arthroplasty compared to selective serotonin reuptake inhibitor among osteoarthritis patients in a large prospective cohort | BMC Medicine | Springer Nature Link
  8. Recommendations | Osteoarthritis in over 16s: diagnosis and management | Guidance | NICE
  9. https://www.aaos.org/oak3cpg
  10. Press Release: Osteoarthritis Treatment Guideline | American College of Rheumatology
  11. Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis - PMC

Original Source(s)

CAA Use Tied to Higher Arthroplasty Risk

  • by Andrea Surnit

  • June 1, 2026

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