Clinical Report: Are the benefits observed with the Endo-App genuinely long-lasting?

Background

Digital interventions like the Endo-App are increasingly explored in pain management for conditions such as endometriosis. Understanding their effectiveness is crucial, as chronic pain management often requires multimodal approaches. However, the interpretation of results from such interventions must be approached with caution due to potential biases and methodological limitations.

Data Highlights

No numerical or trial data presented in the article.

Key Findings

• Self-reported mean pain decreased by 0.80 points after 3 months and 0.85 points after 6–7 months, based on participant responses.
• Relative reductions in pain scores were approximately 14%, with small effect sizes (Cohen’s d = 0.28).
• Significant declines in sick days (p = 0.04) and days requiring medical assistance (p = 0.03) were noted by 6–7 months.
• Attrition from 143 participants at 3 months to 55 at 6–7 months raises concerns about the representativeness of the findings.
• Nominally significant results did not meet a Bonferroni-adjusted threshold, indicating exploratory findings.
• Improvement in a single global pain score cannot be confidently attributed to endometriosis-related pain without further delineation of pain phenotypes.

Clinical Implications

Further longitudinal assessments and responder analyses are necessary to clarify the app's clinical relevance.

Conclusion

Further research is essential to establish the app's efficacy in pain management for endometriosis.

Related Resources & Content

1. Nigdelis, A. et al., Real-word evidence on the effectiveness of the Endo-App in reducing endometriosis-related complaints: a retrospective analysis, 2023 -- Title
2. ACOG, ACOG Publishes New Endometriosis Clinical Guidance, Aiming to Shorten Time to Diagnosis and Improve Access to Care, 2026 -- Title
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7. ACOG Publishes New Endometriosis Clinical Guidance, Aiming to Shorten Time to Diagnosis and Improve Access to Care | ACOG
8. Telehealth cognitive behavioural therapy improves health-related quality of life and pain in endometriosis: the Healing Pelvic Pain Intervention (HaPPI)—a randomized controlled trial - PMC
9. Real-word evidence on the effectiveness of the Endo-App in reducing endometriosis-related complaints: a retrospective analysis - PMC