Targeted Multilayered Adipose Grafting for Effective Facial Rejuvenation

Overview

This retrospective study of 105 patients demonstrates that strategically applying different processed adipose products to specific facial layers yields significant aesthetic improvements with high patient satisfaction and minimal complications. The use of stromal vascular fraction gel (SVF-gel) enhanced periorbital rejuvenation and skin quality, while high-density fat (HDF) and adipose matrix complex (AMC) provided durable structural support.

Background

Facial aging involves complex volumetric changes including soft tissue atrophy and skeletal remodeling, leading to contour deformities that impact patient self-esteem. Autologous fat grafting (AFG) has become a preferred technique for facial rejuvenation due to its biocompatibility and natural results, but unpredictable graft retention remains a challenge. Different processed adipose products, such as macrofat, microfat, nanofat, and SVF-gel, offer distinct biological properties that can be matched to anatomical requirements to optimize outcomes. This study explores the targeted use of multilayered adipose grafting to address both volume deficits and skin quality.

Data Highlights

Key Findings

• All 105 patients experienced significant aesthetic improvement after targeted multilayered adipose grafting.
• SVF-gel was particularly effective for periorbital rejuvenation and improving skin quality.
• HDF and AMC provided stable and durable structural support in deeper facial regions.
• Patient satisfaction scores improved significantly from 5.26 ± 1.84 preoperatively to 8.01 ± 1.09 postoperatively.
• Observer-rated Global Aesthetic Improvement Scale scores averaged 1.88 ± 0.65 postoperatively, indicating marked improvement.
• Sixteen patients required secondary procedures due to partial volume absorption, but no major complications were reported.

Clinical Implications

The study supports the clinical benefit of tailoring adipose grafting products to specific facial layers based on their biological characteristics to optimize volumetric restoration and skin rejuvenation. Incorporating SVF-gel can enhance skin quality and periorbital outcomes, while HDF and AMC ensure long-lasting structural support. This multilayered approach may improve predictability and patient satisfaction in facial fat grafting procedures.

Conclusion

Targeted multilayered adipose grafting using processed fat products matched to anatomical needs offers a comprehensive and effective strategy for facial rejuvenation, addressing both volume loss and skin quality with high safety and patient satisfaction.

References

1. Coleman SR, 1990s -- Autologous Fat Grafting Techniques
2. Henan University of Chinese Medicine, 2025 -- Targeted Use of Multilayered Adipose Grafting for Facial Rejuvenation: A Retrospective Analysis