Custom GPT models for complex rheumatology systematic reviews: A two-part evaluation of data extraction and prognosis appraisal - Report - MDSpire

Custom GPT models for complex rheumatology systematic reviews: A two-part evaluation of data extraction and prognosis appraisal

  • By

  • Pamela Munguía-Realpozo

  • Edith Ramírez-Lara

  • Claudia Mendoza-Pinto

  • Ivet Etchegaray-Morales

  • Juan Carlos Solis-Poblano

  • Marco Alejandro Trinidad-González

  • Jorge Ayón-Aguilar

  • Máximo Alejandro García-Flores

  • Álvaro José Montiel-Jarquín

  • July 9, 2026

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Clinical Report: Evaluation of Tailored GPT Models for Systematic Reviews in Rheumatology

Overview

This study evaluates the performance of customized GPT-based models in data extraction and risk-of-bias appraisal for systematic reviews in rheumatology.

Background

Systematic reviews are essential for evidence-based decision-making in rheumatology, yet they are resource-intensive, particularly in data extraction and risk-of-bias assessment. The complexity of diseases like systemic lupus erythematosus (SLE) adds to the challenges faced by reviewers. Recent advancements in large language models (LLMs) present an opportunity to streamline these processes, but their effectiveness in real-world applications requires thorough evaluation.

Data Highlights

No numerical data was provided in the source material.

Key Findings

  • Customized GPT-based models were evaluated against human reviewers in rheumatology systematic reviews.
  • The study focused on two components: data extraction from metabolomics studies and QUIPS-based risk-of-bias appraisal.
  • Fifteen full-text articles were selected for the data extraction analysis, reflecting diverse study designs.
  • Nineteen full-text studies were included for the QUIPS component, requiring independent assessments by trained reviewers.

Clinical Implications

It is crucial to maintain human oversight to ensure the accuracy and reliability of data extraction and risk assessments.

Conclusion

The study emphasizes the importance of human expertise in the review process.

Related Resources & Content

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  2. Clinical Rheumatology, 2024 -- Predictors of Treatment Efficacy for Biological and Targeted Synthetic DMARDs in Psoriatic Arthritis: A Systematic Review and Meta-Analysis
  3. Clinical Rheumatology, 2023 -- Essential Guidelines for Managing Rheumatoid Arthritis: A Systematic Review of Clinical Recommendations
  4. Drug Safety, 2017 -- Evaluating the Effects of Biologics and Tofacitinib on Cardiovascular Risk and Outcomes in Patients with Rheumatic Disorders: A Comprehensive Literature Review
  5. EULAR, 2026 -- Standard Operating Procedures for Guideline Development
  6. PROBAST+AI, 2025 -- An updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods
  7. Management of systemic lupus erythematosus: a systematic literature review informing the 2023 update of the EULAR recommendations
  8. https://www.eular.org/document/download/1413/0e305fd4-cadd-46de-a9c3-58c1e4587ea0/1331
  9. PROBAST+AI: an updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods - PMC
  10. Management of systemic lupus erythematosus: a systematic literature review informing the 2023 update of the EULAR recommendations

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