Correction: Association between systemic immune-inflammation index(SII) and all-cause and cardiovascular mortality in heart failure patients: a single-center retrospective analysis - Report - MDSpire

Correction: Association between systemic immune-inflammation index(SII) and all-cause and cardiovascular mortality in heart failure patients: a single-center retrospective analysis

  • By

  • Junlan Zhang

  • Nan Lyu

  • Yaping Zhang

  • Pan Chen

  • Qianyu Ma

  • Nana Hu

  • Bingxin Men

  • Xiaolei Shi

  • Changsen Wang

  • Jin Zhang

  • May 27, 2026

  • 0 min

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Correction: Link Between Systemic Immune-Inflammation Index and Mortality

Overview

This report corrects the authorship of a study investigating the systemic immune-inflammation index (SII) and its association with mortality in heart failure patients. The study found that higher SII was independently associated with all-cause mortality but not with cardiovascular mortality.

Background

The systemic immune-inflammation index (SII) is an inflammatory biomarker that reflects the balance between immune and inflammatory responses. Understanding its role in heart failure is crucial. Recent guidelines do not include SII among recommended biomarkers for heart failure diagnosis or prognosis.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • Higher log-transformed SII was independently associated with all-cause mortality in heart failure patients (HR 1.59, 95% CI 1.03–2.46).
  • No significant association was found between SII and cardiovascular mortality in the same cohort.
  • Guidelines from 2022-2025 do not recommend SII as a diagnostic or prognostic biomarker for heart failure.

Clinical Implications

Clinicians should be aware of the potential role of SII in assessing mortality risk among heart failure patients, although it is not currently recommended in guidelines. Further research may clarify its utility in clinical practice.

Conclusion

The correction highlights the importance of accurate authorship in research reporting. The findings regarding SII's association with mortality warrant further investigation in larger cohorts.

Related Resources & Content

  1. Zhang J, Lyu N, Zhang Y, et al., Front Cardiovasc Med, 2026 -- Correction: Link Between Systemic Immune-Inflammation Index and Mortality
  2. Frontiers in Cardiovascular Medicine — The association between systemic immune-inflammation index and mortality of elderly chronic bronchitis patients complicated by acute myocardial infarction
  3. Frontiers in Oncology — Association of systemic immune-inflammation index with all-cause mortality in lung cancer patients undergoing radiotherapy: a retrospective cohort study
  4. Frontiers in Cardiovascular Medicine — Development and validation of a prediction model for 1-year all-cause rehospitalisation after discharge in patients with heart failure with preserved ejection fraction based on the systemic immune-inflammation index
  5. The Journal of Clinical Endocrinology & Metabolism — Age-Related Variations in the Relationship Between Systemic Inflammatory Response and Metabolic Syndrome
  6. 2022 AHA/ACC/HFSA Heart Failure Guideline: Key Perspectives - American College of Cardiology
  7. Diagnostic and prognostic value of systemic immune-inflammation index for heart failure: a systematic review and meta-analysis
  8. Frontiers | Association between systemic immune-inflammation index(SII) and all-cause and cardiovascular mortality in heart failure patients: a single-center retrospective analysis
  9. Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology | JACC

Original Source(s)

Correction: Association between systemic immune-inflammation index(SII) and all-cause and cardiovascular mortality in heart failure patients: a single-center retrospective analysis

  • by Junlan Zhang, Nan Lyu, Yaping Zhang, Pan Chen, Qianyu Ma, Nana Hu, Bingxin Men, Xiaolei Shi, Changsen Wang, Jin Zhang

  • May 27, 2026

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