Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: The CARES Pragmatic Cluster - Report - MDSpire

Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: The CARES Pragmatic Cluster

  • By

  • Folasade P. May

  • Suzanne Brodney

  • Jessica J. Tuan

  • Sapna Syngal

  • Andrew T. Chan

  • Beth Glenn

  • Gina Johnson

  • Yuchiao Chang

  • David A. Drew

  • Beverly Moy

  • Nicolette J. Rodriguez

  • Erica T. Warner

  • Adjoa Anyane-Yeboa

  • Chinedu Ukaegbu

  • Anjelica Q. Davis

  • Kimberly Schoolcraft

  • Susan Regan

  • Kelley Le Beaux

  • Ellen T. Lee

  • Roopa Bhat

  • Alexis Gordon

  • Linh K. Phan

  • Andrea Fernanda Cortés Chirino

  • Caylin J. Marotta

  • Rachel G. Z. Kindermann

  • Jennifer S. Haas

  • June 1, 2026

  • 0 min

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Clinical Report: Postal Outreach for Colorectal Cancer Screening in CHCs

Overview

Revise to clarify the comparison between FIT and FIT-DNA outreach and the significance of the screening rate differences.

Background

Colorectal cancer (CRC) is a leading cause of cancer mortality in the U.S., particularly affecting underserved populations. Screening is crucial for reducing incidence and mortality, yet participation rates remain low in community health centers (CHCs). Innovative outreach strategies, such as mailed screening tests, are essential to improve screening rates in these settings.

Data Highlights

GroupScreening Rate at 6 Months
Mailed FIT9.7%
Mailed FIT-DNA30.0%

Key Findings

  • Mailed FIT outreach increased screening completion to 30.0% compared to 9.7% for standard outreach (P < .001).
  • FIT-DNA offers higher sensitivity and is supported by a manufacturer-administered patient assistance program.
  • The study included 8 CHC sites with varying baseline screening rates (23.9% to 66.5%).
  • Participants were aged 45 to 75 years and due for CRC screening.
  • Follow-up colonoscopy rates after abnormal results remain low, indicating a need for improved diagnostic pathways.

Clinical Implications

Healthcare providers in CHCs should consider implementing mailed outreach strategies to enhance CRC screening participation. Additionally, addressing follow-up care for abnormal results is critical to ensure comprehensive patient management.

Conclusion

The CARES study highlights the effectiveness of mailed outreach in increasing CRC screening rates in CHCs, emphasizing the need for continued innovation in patient engagement strategies.

Related Resources & Content

  1. JAMA Network, JAMA Internal Medicine, 2026 -- Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: The CARES Pragmatic Cluster Randomized Clinical Trial
  2. Journal of Medical Internet Research (JMIR), 2026 -- Leveraging Text Messaging and Behavior Theory to Improve Colorectal Cancer Screening in Federally Qualified Health Centers: Cohort Study
  3. The ASCO Post, 2014 -- ASCO Recruits Members to Help Improve Access to Colorectal Cancer Screening, Follow-up Care
  4. The ASCO Post, 2021 -- Colorectal Cancer Screening: Preferences of Gastroenterologists and Primary Care Clinicians
  5. The ASCO Post — Colorectal Cancer Screening: Preferences of Gastroenterologists and Primary Care Clinicians
  6. Colorectal Cancer Screening Guideline Update 2026
  7. Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: The CARES Pragmatic Cluster Randomized Clinical Trial | Trials | JAMA Internal Medicine | JAMA Network
  8. Interventions for Increasing Colorectal Cancer Screening Uptake: A Systematic Review and Network Meta-Analysis - PubMed

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