Evaluation of SPIO-Enhanced MRI in Distinguishing Metastatic Lymph Nodes from Reactive Hyperplasia in Breast Cancer: Diagnostic Efficacy and Correlation with VEGF-C Levels - Report - MDSpire

Evaluation of SPIO-Enhanced MRI in Distinguishing Metastatic Lymph Nodes from Reactive Hyperplasia in Breast Cancer: Diagnostic Efficacy and Correlation with VEGF-C Levels

  • By

  • Tao Wu

  • Angela Wu

  • Hui Xiong

  • Jiaying Deng

  • Zhewen Zhang

  • Dan Gong

  • Jun Luo

  • Dan Wu

  • April 22, 2026

  • 0 min

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Clinical Report: Evaluation of SPIO-Enhanced MRI in Breast Cancer Lymph Nodes

Overview

{'correlation': 'Specify if the correlation between imaging characteristics and VEGF-C expression is direct or indirect.'}

Background

{'limitations': 'Add specific limitations of conventional imaging methods.'}

Data Highlights

{'format': 'Consider using bullet points for clarity.'}

Key Findings

{'context': 'Add significance of the correlation between PSIL and VEGF-C grade.'}

Clinical Implications

{'scenarios': 'Suggest specific patient profiles for SPIO-enhanced MRI use.'}

Conclusion

{'emphasis': 'Highlight the need for larger studies and clinical implications.'}

References

  1. Author(s)/Org, Source, Year -- Title
  2. European Radiology, 2023 -- Imaging Hypoxia and Vascular Dynamics in ER-Positive Breast Cancer Using PET/MRI: Links to Immunohistochemical Findings
  3. BJS (British Journal of Surgery), 2023 -- Evaluation of Ultra-Low Dose Superparamagnetic Iron Oxide Nanoparticle Injection for Sentinel Lymph Node Identification in Breast Cancer: A Prospective Cohort Analysis
  4. European Radiology, 2024 -- Utilization of Ferumoxtran-10-Enhanced MRI for the Detection of Metastatic Lymph Nodes Prior to Surgery in Cases of Pancreatic, Duodenal, or Periampullary Adenocarcinoma
  5. Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update
  6. Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update
  7. Ferumoxtran-10-enhanced MRI for pre-operative metastatic lymph node detection in pancreatic, duodenal, or periampullary adenocarcinoma | European Radiology | Springer Nature Link
  8. Lymphangiogenesis in Breast Cancer: From Molecular Mechanisms to Clinical Implications - PubMed

Original Source(s)

Evaluation of SPIO-Enhanced MRI in Distinguishing Metastatic Lymph Nodes from Reactive Hyperplasia in Breast Cancer: Diagnostic Efficacy and Correlation with VEGF-C Levels

  • by Tao Wu, Angela Wu, Hui Xiong, Jiaying Deng, Zhewen Zhang, Dan Gong, Jun Luo, Dan Wu

  • April 22, 2026

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