Genitourinary symptoms and sexual dysfunction in women with premature ovarian insufficiency: a cross-sectional study with age-comparable controls - Report - MDSpire

Genitourinary symptoms and sexual dysfunction in women with premature ovarian insufficiency: a cross-sectional study with age-comparable controls

  • By

  • Zijie Fu

  • Xueping Liu

  • Wei Guo

  • Yahui Bian

  • Tongyao Geng

  • Bianling Xu

  • Jiabei Hao

  • Xiaodong Li

  • June 22, 2026

  • 0 min

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Clinical Report: Genitourinary Issues and Sexual Dysfunction in POI

Overview

This study characterizes genitourinary symptoms and sexual function in women with premature ovarian insufficiency (POI), revealing a higher prevalence of vulvovaginal dryness and sexual dysfunction compared to age-matched controls.

Background

Premature ovarian insufficiency (POI) affects women under 40, leading to estrogen deficiency and associated health issues, including sexual dysfunction. Understanding genitourinary symptoms in POI is important as they may impact quality of life. Current guidelines emphasize the importance of addressing these symptoms in clinical practice.

Data Highlights

GroupVulvovaginal DrynessFSFI Total ScoreICIQ Total Score
Women with POIHigher prevalenceLower scoresNo significant difference
Age-comparable ControlsLower prevalenceHigher scoresNo significant difference

Key Findings

  • Women with POI reported more frequent vulvovaginal dryness compared to controls.
  • Lower FSFI total scores were observed in women with POI, indicating higher prevalence of sexual dysfunction.
  • Vulvovaginal dryness was independently associated with lower FSFI scores (B = -0.804, P < 0.001).
  • No significant differences in urinary incontinence severity were found between the groups.
  • Impairments in arousal, lubrication, orgasm, satisfaction, and pain were noted among women with POI.

Clinical Implications

Clinicians should assess genitourinary symptoms and sexual function in women with POI.

Conclusion

The study highlights the burden of genitourinary symptoms and sexual dysfunction in women with POI, particularly vulvovaginal dryness.

Related Resources & Content

  1. American Society for Reproductive Medicine, ASRM, 2025 -- Evidence-based guideline: Premature Ovarian Insufficiency
  2. American Urological Association, AUA/SUFU/AUGS, 2025 -- Genitourinary Syndrome of Menopause: AUA/SUFU/AUGS Guideline
  3. Assessing the Effects of Urogenital Organ Displacement Following Abdominoperineal Resection on Urinary and Sexual Function
  4. World Journal of Urology — Recurrent UTI quality of life questionnaire: pilot study evaluating the impact of recurrent urinary tract infection on quality of life in postmenopausal women
  5. Clinical Rheumatology — Assessment of Ovarian Reserve in Women Diagnosed with Sjögren’s Syndrome: A Cross-Sectional Analysis
  6. Frontiers in Medicine — Menstrual Cycle Patterns in Primary Care: A Structured Approach Using Primary Ovarian Insufficiency as a Sentinel Condition
  7. Evidence-based guideline: Premature Ovarian Insufficiency (2025) | American Society for Reproductive Medicine | ASRM
  8. Genitourinary Syndrome of Menopause: AUA/SUFU/AUGS Guideline
  9. https://pure.eur.nl/ws/portalfiles/portal/147797279/Sexual_function_in_women_with_premature_ovarian_insufficiency_POI_.pdf

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