Inpatient Characteristics and Outcomes of Venous Thromboembolism Among Children and Adolescents - Report - MDSpire

Inpatient Characteristics and Outcomes of Venous Thromboembolism Among Children and Adolescents

  • By

  • Sabrina Friebe

  • Dierk Scheinert

  • Esra Tokur Sonuvar

  • Toralf Kirsten

  • Eva Freisinger

  • June 9, 2026

  • 0 min

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Characteristics and Outcomes of Venous Thromboembolism in Hospitalized Pediatric Patients

Overview

This study investigates the incidence and characteristics of venous thromboembolism (VTE) in hospitalized pediatric patients, revealing significant risk factors and outcomes associated with this condition. The findings highlight the need for improved management strategies and guidelines tailored specifically for the pediatric population.

Background

Venous thromboembolism (VTE) is a serious condition that can lead to significant morbidity and mortality, particularly in hospitalized pediatric patients. While VTE is rare in children compared to adults, its incidence is increasing, especially among neonates and adolescents. Understanding the characteristics and outcomes of VTE in this demographic is crucial for developing effective prevention and treatment strategies.

Data Highlights

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Key Findings

  • VTE incidence in pediatric patients is reported at 1.4 to 4.9 per 100,000 children annually.
  • Neonates have a higher occurrence of VTE compared to older children, with rates of 5.1 per 100,000 births.
  • Risk factors for VTE include genetic disorders, obesity, immobility, and the use of central venous catheters.
  • Management of VTE in children often relies on extrapolated adult data due to a lack of pediatric-specific studies.
  • There are currently no uniform standards of care for VTE management in children, leading to variability in treatment approaches.

Clinical Implications

Healthcare providers should be aware of the increasing incidence of VTE in pediatric patients and the associated risk factors. It is essential to implement targeted prevention strategies, especially in high-risk groups such as neonates and adolescents, to reduce the occurrence of VTE and its complications.

Conclusion

The study underscores the need for enhanced awareness and tailored management strategies for VTE in pediatric patients. Continued research is necessary to establish standardized care protocols and improve patient outcomes.

Related Resources & Content

  1. JAMA Network Open, 2023 -- Factors Associated With Thromboembolism in Neonates: A Systematic Review and Meta-Analysis
  2. Frontiers in Cardiovascular Medicine, 2026 -- Detected residual venous thrombi and catheter-directed management of intermediate-risk pulmonary thromboembolism
  3. Frontiers in Pediatrics, 2026 -- Outcomes of critically ill pediatric patients after haploidentical stem cell transplantation
  4. Burden and management of venous thromboembolism in children and adolescents (2004–2023): a Swiss nationwide epidemiological study, European Journal of Pediatrics
  5. ASH CPG VTE peds Visual Summary 0430, 2025 -- ASH Guidelines Update
  6. Pediatric Cardiology — Evaluating the Safety of Ongoing Anticoagulation in Pediatric Cardiac Catheterization: Insights from a Los Angeles Medical Center
  7. Burden and management of venous thromboembolism in children and adolescents (2004–2023): a Swiss nationwide epidemiological study | European Journal of Pediatrics | Springer Nature Link
  8. ASH CPG VTE peds Visual Summary 0430
  9. Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial - PubMed

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