Advantages of Using Minimal Ethanol Volume with Retention in Transvaginal Ethanol Sclerotherapy for Endometriomas - Report - MDSpire

Advantages of Using Minimal Ethanol Volume with Retention in Transvaginal Ethanol Sclerotherapy for Endometriomas

  • By

  • Hwa Sook Moon

  • Bo Sun Joo

  • Jaseong Koo

  • Kyung Il Nam

  • Joshua Bonwoo Koo

  • Sang Gap Kim

  • April 29, 2026

  • 0 min

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Clinical Report: Advantages of Using Minimal Ethanol Volume in Sclerotherapy

Overview

This study evaluates the effectiveness of transvaginal ethanol sclerotherapy for endometriomas, emphasizing the benefits of using minimal ethanol volume and retention. Findings indicate that this approach significantly reduces recurrence rates and minimizes the impact on ovarian reserve, as measured by AMH levels.

Background

Ovarian endometriomas affect a significant proportion of women with infertility, presenting challenges in treatment due to their complex nature. Traditional surgical methods, while effective, often compromise ovarian reserve, necessitating the exploration of less invasive alternatives. Ethanol sclerotherapy has emerged as a promising option, particularly for preserving fertility and minimizing damage to ovarian tissue.

Data Highlights

YearCasesAMH Follow-up
2015-202242190

Key Findings

  • Transvaginal sclerotherapy using 95% ethanol was performed on 421 cases.
  • Retention of ethanol without removal showed lower recurrence rates compared to traditional methods.
  • Minimal ethanol volume was associated with reduced impact on AMH levels.
  • Patients had endometriomas ranging from 2.5 to 10.6 cm.
  • Effective aspiration of viscous cystic content is crucial for successful outcomes.

Clinical Implications

Clinicians should consider transvaginal ethanol sclerotherapy as a viable option for treating ovarian endometriomas, particularly in patients wishing to preserve fertility. The technique's focus on minimal ethanol volume and retention can lead to better outcomes with fewer complications.

Conclusion

The study supports the use of minimal ethanol volume and retention in transvaginal sclerotherapy as an effective strategy for managing endometriomas, highlighting its potential to reduce recurrence and protect ovarian function.

References

  1. ESHRE, ESHRE Guidelines, 2022 -- Endometriosis
  2. Archives of Gynecology and Obstetrics, 2025 -- Ultrasound-guided ethanol sclerotherapy versus laparoscopic surgery for endometriomas
  3. Surgical Endoscopy — Innovative Techniques in Endoscopic Treatment of Esophageal Varices: A Randomized Prospective Study on Balloon Compression-Assisted Sclerotherapy and Variceal Ligation
  4. Evaluation of Endoscopic Vacuum Therapy Versus Standard Treatment for Managing Leakage Following Rectal Resection
  5. Retinal Physician — Comparison of Traditional Pars Plana Vitrectomy to a Transconjunctival Approach
  6. Retinal Physician — Controversies in Care
  7. https://www.eshre.eu/-/media/sitecore-files/Guidelines/Endometriosis/ESHRE-GUIDELINE-ENDOMETRIOSIS-2022_1.pdf
  8. Ultrasound-guided ethanol sclerotherapy versus laparoscopic surgery for endometriomas: a randomized clinical trial in a real-world setting | Archives of Gynecology and Obstetrics | Springer Nature Link

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