Assessment of Glucose Metabolism, Endocrine, and Renal Function After Vaccination in Individuals with Post-COVID-19: A Longitudinal Retrospective Study from a Single Center - Report - MDSpire

Assessment of Glucose Metabolism, Endocrine, and Renal Function After Vaccination in Individuals with Post-COVID-19: A Longitudinal Retrospective Study from a Single Center

  • By

  • Ceren Gür

  • Sezen Kumaş Solak

  • December 29, 2025

  • 0 min

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Clinical Report: Assessment of Glucose Metabolism and Renal Function Post-COVID-19

Overview

This study evaluates the impact of vaccination on glucose metabolism, endocrine, and renal function in COVID-19 survivors. It highlights significant differences in biomarker levels based on vaccination status over a 30-month period.

Background

COVID-19 can lead to systemic complications affecting multiple organ systems, including metabolic and endocrine dysfunctions. Understanding the long-term effects of COVID-19, particularly in vaccinated individuals, is crucial for managing post-acute sequelae and informing public health strategies. This study aims to fill the gap in knowledge regarding the relationship between vaccination status and biomarker alterations in COVID-19 survivors.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

  • Vaccination status significantly influences metabolic and inflammatory biomarkers in COVID-19 survivors.
  • Individuals receiving three or more vaccine doses exhibited better metabolic control compared to unvaccinated individuals.
  • Longitudinal tracking revealed persistent alterations in glucose metabolism and renal function post-infection.
  • Biochemical markers such as creatinine, urea, and thyroid hormones were affected by vaccination status.
  • Vaccination may mitigate long-term complications associated with COVID-19, including dysglycemia and renal impairment.

Clinical Implications

Healthcare providers should consider vaccination status when evaluating post-COVID-19 patients for metabolic and renal dysfunction. Enhanced monitoring of biomarkers in vaccinated individuals may lead to improved management strategies and outcomes.

Conclusion

This study underscores the importance of vaccination in mitigating long-term health issues following COVID-19, particularly concerning glucose metabolism and renal function. Further research is needed to explore the mechanisms underlying these changes.

References

  1. Open Forum Infectious Diseases, 2023 -- Cognitive Abilities One Year Post-COVID-19 Infection
  2. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Altered Glucagon Release Plays a Role in the Progressive Deterioration of Glucose Tolerance
  3. Open Forum Infectious Diseases, 2023 -- Association of Viral Load and Disease Severity in Acute SARS-CoV-2 Infection with the Development of Long COVID Symptoms
  4. Long COVID Clinical Guidance | Long COVID | CDC, 2026
  5. Nature, 2025 -- Prevalence of new-onset diabetes following COVID-19 infection: A systematic review and meta-analysis
  6. The Journal of Clinical Endocrinology & Metabolism — Variations in Glucagon Secretion Following Oral Glucose in Individuals Across Different Phases of Type 1 Diabetes Progression
  7. Long COVID Clinical Guidance | Long COVID | CDC
  8. Prevalence of new-onset diabetes following COVID-19 infection: A systematic review and meta-analysis
  9. Article https://doi.org/10.1038/s41467-025-65302-0

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