Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study - Report - MDSpire

Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study

  • By

  • Qiaozhi Jin

  • Ziyuan Chen

  • Yong Li

  • Yilong Wang

  • Changyu Duan

  • Yongjie Ying

  • Fude Jin

  • June 15, 2026

  • 0 min

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Clinical Report: Simplified Nomogram for Forecasting BPPV Recurrence

Overview

This study developed a simplified nomogram to predict recurrence of Benign Paroxysmal Positional Vertigo (BPPV) based on key risk factors. The model was externally validated and demonstrated high accuracy in identifying patients at risk for recurrence.

Background

BPPV is a common vestibular disorder with significant recurrence rates following treatment, impacting patient quality of life. Understanding the risk factors associated with recurrence is crucial for developing effective secondary prevention strategies. This study addresses the need for a comprehensive prognostic tool that integrates various predictors of BPPV recurrence.

Data Highlights

VariableOdds Ratio (OR)
Diabetes Mellitus11.42
Non-posterior canal involvement4.17
25-hydroxyvitamin D deficiency3.76

Key Findings

  • The 1-year recurrence rate for BPPV was found to be 23.97%.
  • The nomogram included three significant predictors: Diabetes Mellitus, Non-posterior canal involvement, and 25-hydroxyvitamin D deficiency.
  • The model achieved an AUC of 0.905 in the training set, indicating excellent discrimination.
  • Calibration curves showed strong agreement between predicted and observed probabilities.
  • Decision Curve Analysis confirmed the model's clinical utility across various threshold probabilities.

Clinical Implications

Healthcare providers can utilize this nomogram to identify high-risk BPPV patients, enabling personalized management strategies. Early intervention based on risk stratification may reduce recurrence rates and improve patient outcomes.

Conclusion

The developed nomogram offers a valuable tool for clinicians to predict BPPV recurrence, facilitating targeted prevention efforts. Its external validation underscores its potential for clinical application.

Related Resources & Content

  1. Bhattacharyya et al., AAO-HNS, 2017 -- Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) Executive Summary
  2. Identifying key risk factors for the recurrence of benign paroxysmal positional vertigo following successful canalith repositioning maneuvers: a meta analysis - PMC
  3. Frontiers | Risk factors and a nomogram model for recurrence of benign paroxysmal positional vertigo: a multicenter cross-sectional study
  4. Creation and assessment of a nomogram for forecasting early stress urinary incontinence after endoscopic prostate enucleation
  5. Frontiers in Oncology — Development and internal validation of a risk prediction model for ipsilateral upper-limb lymphedema following breast cancer surgery
  6. Frontiers in Surgery — Constructing a nomogram for forecasting incomplete clinical recovery following unilateral biportal endoscopy in lumbar disc herniation cases
  7. Surgical Endoscopy (Springer) — Creation and temporal assessment of a clinical nomogram for forecasting prolonged hospitalization following bariatric surgery
  8. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) Executive Summary - Neil Bhattacharyya, Samuel P. Gubbels, Seth R. Schwartz, Jonathan A. Edlow, Hussam El-Kashlan, Terry Fife, Janene M. Holmberg, Kathryn Mahoney, Deena B. Hollingsworth, Richard Roberts, Michael D. Seidman, Robert W. Prasaad Steiner, Betty Tsai Do, Courtney C. J. Voelker, Richard W. Waguespack, Maureen D. Corrigan, 2017
  9. Identifying key risk factors for the recurrence of benign paroxysmal positional vertigo following successful canalith repositioning maneuvers: a meta analysis - PMC
  10. Frontiers | Risk factors and a nomogram model for recurrence of benign paroxysmal positional vertigo: a multicenter cross-sectional study

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