Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study - Report - MDSpire
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Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study
Clinical Report: Simplified Nomogram for Forecasting BPPV Recurrence
Overview
This study developed a simplified nomogram to predict recurrence of Benign Paroxysmal Positional Vertigo (BPPV) based on key risk factors. The model was externally validated and demonstrated high accuracy in identifying patients at risk for recurrence.
Background
BPPV is a common vestibular disorder with significant recurrence rates following treatment, impacting patient quality of life. Understanding the risk factors associated with recurrence is crucial for developing effective secondary prevention strategies. This study addresses the need for a comprehensive prognostic tool that integrates various predictors of BPPV recurrence.
Data Highlights
Variable
Odds Ratio (OR)
Diabetes Mellitus
11.42
Non-posterior canal involvement
4.17
25-hydroxyvitamin D deficiency
3.76
Key Findings
The 1-year recurrence rate for BPPV was found to be 23.97%.
The nomogram included three significant predictors: Diabetes Mellitus, Non-posterior canal involvement, and 25-hydroxyvitamin D deficiency.
The model achieved an AUC of 0.905 in the training set, indicating excellent discrimination.
Calibration curves showed strong agreement between predicted and observed probabilities.
Decision Curve Analysis confirmed the model's clinical utility across various threshold probabilities.
Clinical Implications
Healthcare providers can utilize this nomogram to identify high-risk BPPV patients, enabling personalized management strategies. Early intervention based on risk stratification may reduce recurrence rates and improve patient outcomes.
Conclusion
The developed nomogram offers a valuable tool for clinicians to predict BPPV recurrence, facilitating targeted prevention efforts. Its external validation underscores its potential for clinical application.