Longitudinal Patterns of Impaired Fasting Glucose and Their Relationship with Cardio-Kidney-Metabolic Multimorbidity Risk
Overview
Revise to specify the findings regarding the association of IFG with multimorbidity risk more clearly.
Background
Impaired fasting glucose (IFG) is a critical metabolic state that can lead to type 2 diabetes and cardiovascular disease. Understanding the longitudinal patterns of IFG is essential as it can inform strategies for preventing multimorbidity, which is increasingly prevalent in aging populations. The study highlights the importance of monitoring IFG to mitigate long-term health risks.
Data Highlights
IFG Status
Adjusted HR (95% CI)
Sustained Normal
1.00
IFG Progression
1.93 (1.72–2.17)
IFG Recovery
1.69 (1.44–1.98)
Persistent IFG
3.10 (2.74–3.52)
Key Findings
1,795 participants developed CKM multimorbidity over a median follow-up of 11 years.
Persistent IFG was associated with the highest risk of multimorbidity (HR 3.10).
IFG recovery showed a lower risk compared to persistent IFG but remained higher than sustained normal fasting glucose (HR 1.69).
IFG progression did not show a statistically significant association with multimorbidity risk (HR 1.14).
Preventing the onset of IFG is crucial for reducing long-term multisystem damage.
Clinical Implications
Clinicians should prioritize early detection and prevention of IFG to reduce the risk of CKM multimorbidity. Continuous monitoring of fasting glucose levels is essential, even after recovery from IFG, to ensure long-term health outcomes.
Conclusion
The study underscores the importance of managing IFG to prevent the development of cardio-kidney-metabolic multimorbidity. Timely intervention and sustained maintenance of normal fasting glucose levels are critical for patient health.
