Case Study of Isolated Littoral Cell Angioma of the Spleen in a Pediatric Patient
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By
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Huihui Lin
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Xiaoyu Wang
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Longxiu Zhang
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June 16, 2026
Clinical Report: Case Study of Isolated Littoral Cell Angioma of the Spleen
Overview
This report details a case of isolated splenic littoral cell angioma (LCA) in a 9-year-old male, diagnosed after incidental discovery during a physical examination. Surgical resection was performed, and no recurrence was noted at follow-up.
Background
Littoral cell angioma is a rare primary vascular tumor of the spleen, particularly uncommon in pediatric patients. Most cases are asymptomatic and diagnosed incidentally, leading to potential misdiagnosis. Understanding the clinical and imaging characteristics of LCA is crucial for accurate diagnosis and management.
Data Highlights
| Parameter | Value |
|---|---|
| Lesion Size | 4.8 cm × 4.8 cm × 5.3 cm |
| Platelet Count | 454×109/L |
| Plain CT Value | ~43 HU |
| Arterial Phase CT Value | ~182 HU |
| Portal Venous Phase CT Value | ~133 HU |
| Delayed Phase CT Value | ~98 HU |
Key Findings
- Isolated LCA is rare in pediatric patients, with most cases being asymptomatic.
- The tumor was confirmed through pathological examination and immunohistochemistry.
- CT imaging showed characteristic enhancement patterns, aiding in diagnosis.
- Surgical resection resulted in no recurrence at 3 and 6 months postoperatively.
- Definitive diagnosis relies on pathology, highlighting the importance of surgical intervention.
Clinical Implications
Healthcare professionals should consider LCA in differential diagnoses for splenic lesions in children, especially when imaging shows characteristic enhancement patterns. Surgical resection remains the primary treatment approach.
Conclusion
This case emphasizes the importance of recognizing isolated LCA in pediatric patients and the role of imaging and pathology in diagnosis and management.
Related Resources & Content
- Frontiers in Oncology, 2026 -- Interventional treatment for littoral cell angioma of spleen-induced thrombocytopenia: a case report and literature review
- Frontiers in Oncology, 2026 -- A case report of splenic malignancy originating from the liver
- Littoral cell angioma unveiled: Exploring diagnosis, treatment, and malignant potential - ScienceDirect
- Frontiers | Case report and literature review: Asymptomatic littoral cell angioma in a 3-year-old girl
- Pediatric Inflammatory Myofibroblastic Tumors of the Colon: Clinical Features, Treatment Approaches, and Outcomes—A Case Study with a Comprehensive Literature Review
- Updates in Surgery — Utilization of the Alexis® System for Pediatric Laparoscopic Splenectomy
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- Littoral cell angioma unveiled: Exploring diagnosis, treatment, and malignant potential - ScienceDirect
- Frontiers | Case report and literature review: Asymptomatic littoral cell angioma in a 3-year-old girl
Based on findings from:
Isolated splenic littoral cell angioma in a child: a case report
Huihui Lin, Xiaoyu Wang, Longxiu Zhang. Frontiers In Oncology, 2026.
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1770088/full
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