Immunoadsorption and subsequent immunoglobulin G replacement (IA/IG) in patients with dilated cardiomyopathy: a systematic review and meta-analysis - Report - MDSpire

Immunoadsorption and subsequent immunoglobulin G replacement (IA/IG) in patients with dilated cardiomyopathy: a systematic review and meta-analysis

  • By

  • Xiao Xia

  • Yuhao Yao

  • Jun Li

  • Shiyi Tao

  • Xuanchun Huang

  • Chao Meng

  • Yiying Liu

  • Yonghao Li

  • Ruikang Liu

  • June 23, 2026

  • 0 min

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Clinical Report: Evaluation of Immunoadsorption and Immunoglobulin G Replacement Therapy in DCM

Overview

This systematic review and meta-analysis evaluates the efficacy of immunoadsorption combined with immunoglobulin G replacement therapy (IA/IG) in patients with dilated cardiomyopathy (DCM). The findings indicate significant improvements in left ventricular ejection fraction and other cardiac function metrics.

Background

Dilated cardiomyopathy (DCM) is a serious cardiac condition associated with high morbidity and mortality rates. Current treatment options are limited, especially for end-stage DCM patients who often do not respond adequately to pharmacologic therapies.

Data Highlights

OutcomeMean Difference (MD)95% Confidence Interval (CI)p-value
Left Ventricular Ejection Fraction (LVEF)7.71%6.18–9.24< 0.00001
Left Ventricular End-Diastolic Dimension (LVEDD)-3.22 mm-4.16 to -2.28< 0.00001
NYHA Functional Class-0.76-0.91 to -0.60< 0.00001
Peak VO₂2.66 mL/kg/min1.26–4.060.0002

Key Findings

  • IA/IG therapy significantly improved LVEF by 7.71% from baseline.
  • IA/IG therapy reduced LVEDD by 3.22 mm.
  • Improvements in NYHA functional class were noted with a mean difference of -0.76.
  • Peak VO₂ increased by 2.66 mL/kg/min with IA/IG therapy.
  • Compared to controls, the IA/IG group showed greater improvements in LVEF (8.31%) and NYHA class (-0.62).

Clinical Implications

The findings indicate a need for further research to validate these results and establish standardized treatment protocols.

Conclusion

Further high-quality trials are essential to confirm these findings and assess long-term benefits.

Related Resources & Content

  1. Clinical Research in Cardiology, 2021 -- Outcomes of Heart Transplantation in Patients with Cardiac Sarcoidosis and Giant-Cell Myocarditis: A Systematic Review and Meta-Analysis of Short- and Long-Term Results
  2. Basic Research in Cardiology, 2019 -- Interventions to Mitigate Myocardial Damage in Animal Models of Myocarditis: A Systematic Review and Meta-Analysis
  3. Clinical Research in Cardiology, 2021 -- The Importance of Prompt and Personalized Management of Heart Failure: A Call for Integration into Updated Guidelines
  4. npj Digital Medicine, 2026 -- Development and validation of a machine learning-based scoring system to assess the diagnostic efficacy of endomyocardial biopsy
  5. 2025 ESC Guidelines for the management of myocarditis and pericarditis
  6. European Heart Journal, 2026 -- IASO-DCM phase 2 trial results
  7. Frequency of autoantibodies and their associated clinical characteristics and outcomes in patients with dilated cardiomyopathy: A systematic review and meta-analysis
  8. https://www.escardio.org/static-file/Escardio/Guidelines/Products/Slide%20sets/2025/2025%20official%20slides_MyoPeri.pdf
  9. https://academic.oup.com/eurheartj/article/47/19/2391/8494636
  10. Frequency of autoantibodies and their associated clinical characteristics and outcomes in patients with dilated cardiomyopathy: A systematic review and meta-analysis - ScienceDirect

Original Source(s)

Immunoadsorption and subsequent immunoglobulin G replacement (IA/IG) in patients with dilated cardiomyopathy: a systematic review and meta-analysis

  • by Xiao Xia, Yuhao Yao, Jun Li, Shiyi Tao, Xuanchun Huang, Chao Meng, Yiying Liu, Yonghao Li, Ruikang Liu

  • June 23, 2026

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