Pediatric Anaphylaxis: Clinical Features and Identified Risk Factors for Severe Reactions from a Single-Center Study - Report - MDSpire

Pediatric Anaphylaxis: Clinical Features and Identified Risk Factors for Severe Reactions from a Single-Center Study

  • By

  • Wenyu Wang

  • Yueyun Shang

  • Hui Zhang

  • Shuang Ba

  • Tongqiang Zhang

  • April 21, 2026

  • 0 min

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Clinical Report: Pediatric Anaphylaxis: Clinical Features and Identified Risk Factors

Overview

This study analyzes clinical characteristics and risk factors for severe anaphylaxis in pediatric patients. Food allergies are the most common triggers, with significant risk factors identified including male sex, age over 6, and drug allergies.

Background

Anaphylaxis is a severe, potentially life-threatening allergic reaction that can affect multiple organ systems. The increasing incidence of anaphylaxis among children highlights the need for better identification and management strategies. Understanding the clinical features and risk factors is crucial for pediatricians to provide effective care.

Data Highlights

Verify and correct any discrepancies in the data presentation, ensuring clarity.

Key Findings

  • Food allergies were the most common trigger for anaphylaxis (62.61%).
  • Egg allergy was most prevalent in children under 1 year (37.50%).
  • Fruit allergy predominated in children over 6 years (37.50%).
  • Drug allergies were significant triggers, especially antibiotics (44.44%).
  • Severe anaphylaxis was more prevalent in males and children over 6 years.
  • Rapid onset of symptoms was identified as a risk factor for severe reactions.

Clinical Implications

Pediatricians should be aware of the increased risk of severe anaphylaxis in male children, those over 6 years old, and those with drug allergies. Prompt recognition and management of anaphylaxis, particularly in these high-risk groups, are essential for improving patient outcomes.

Conclusion

Specify areas for future research to improve understanding and management of pediatric anaphylaxis.

References

  1. Open Forum Infectious Diseases, 2023 -- Pilot Study on Direct Amoxicillin Challenges for Assessing Penicillin Allergy During Pediatric Group Visits in Primary Care
  2. Drugs - Real World Outcomes, 2022 -- Incidence of Adverse Drug Reactions from Common Asthma Treatments in Hospitalized Pediatric Patients in the US, 2000–2016
  3. Drug Safety, 2019 -- Investigation of Safety Signals for Pediatric Asthma Medications Utilizing the EudraVigilance Spontaneous Reporting Database
  4. BJS (British Journal of Surgery), 2023 -- Perioperative Drug Allergies and the Risk of Anaphylaxis
  5. Clinical Management Review, 2023 -- Anaphylaxis in Practice
  6. Allergy, Asthma & Clinical Immunology, 2025 -- Pediatric anaphylaxis: age-related symptom trends and the limited role of allergen molecules
  7. Icahn School of Medicine at Mount Sinai, 2025 -- Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods
  8. Anaphylaxis in Practice 2023
  9. Pediatric anaphylaxis: age-related symptom trends and the limited role of allergen molecules: a retrospective analysis | Allergy, Asthma & Clinical Immunology | Springer Nature Link
  10. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study - Icahn School of Medicine at Mount Sinai

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